Thrombus Precursor Protein and Clinical Outcomes in Patients With Acute Coronary Syndromes
Jessica L. Mega, MD, MPH*,*,
David A. Morrow, MD, MPH, FACC*,
James A. de Lemos, MD, FACC ,
Satishkumar Mohanavelu, MS*,
Christopher P. Cannon, MD, FACC* and
Marc S. Sabatine, MD, MPH, FACC*
* TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts
Division of Cardiology, Department of Medicine, University of Texas, Southwestern Medical Center, Dallas, Texas.
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Figure 2 Cumulative Incidence of the Composite Outcome by TpP Level
Cumulative incidence of the composite outcome (death, myocardial infarction, ischemia requiring revascularization, or ischemia requiring rehospitalization) through 10 months stratified by TpP levels  median (8.9 µg/ml) or > median. CI = confidence interval; HR = hazard ratio; TpP = thrombus precursor protein.
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Figure 3 Rates of Death or MI by TpP Level
Nelson-Aalen event rates through 10 months for death or myocardial infarction for patients with TpP levels median (8.9 µg/ml) or > median. MI = myocardial infarction; other abbreviations as in Figure 2.
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Figure 4 Hazard Ratios for the Composite Outcome in Subgroups by TpP Level
Hazard ratio plot for the risk of the composite outcome (death, myocardial infarction, ischemia requiring revascularization, or ischemia requiring rehospitalization) with a TpP > median (8.9 µg/ml) in specified subgroups. The p value to test for interaction was >0.18 for all subgroups. CAD = coronary artery disease; CI = confidence interval; LMWH = low molecular weight heparin; NSTEMI-UA = non–ST-segment elevation myocardial infarction–unstable angina; STEMI = ST-segment elevation myocardial infarction; SX = symptoms; TpP = thrombus precursor protein; TX = treatment; UFH = unfractionated heparin.
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