Late Gadolinium Enhancement by Cardiovascular Magnetic Resonance Heralds an Adverse Prognosis in Nonischemic Cardiomyopathy
Katherine C. Wu, MD, FACC*,*,
Robert G. Weiss, MD*, ,
David R. Thiemann, MD*, ,
Kakuya Kitagawa, MD*,
André Schmidt, MD*,
Darshan Dalal, MD*,
Shenghan Lai, MD, PhD ,
David A. Bluemke, MD, PhD*,,
Gary Gerstenblith, MD, FACC*,
Eduardo Marbán, MD, PhD, FACC*,
Gordon F. Tomaselli, MD, FACC and
João A.C. Lima, MD, FACC*,
* Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland
Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland
Department of Epidemiology, Johns Hopkins Medical Institutions, Baltimore, Maryland.
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Figure 1 CMR Late Gadolinium Enhancement Patterns Observed in the Study Group
(A) Predominantly midwall enhancement involving the septal, anterior, and anterolateral walls. (B) Apical-lateral near-transmural enhancement (subendocardial to epicardial enhancement). (C) Patterns of patchy foci not following an epicardial coronary perfusion territory. (C1) There is a focus of midlateral wall enhancement. (C2) There is basal septal enhancement. Arrows indicate regions of late gadolinium enhancement.
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Figure 2 Kaplan-Meier Event-Free Survival Curve for the Occurrence of an Index Composite Event
Patients are grouped by presence or absence of cardiovascular magnetic resonance late gadolinium enhancement. Wilcoxon-Breslow: p < 0.001 for the 2 survival curves.
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