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J Am Coll Cardiol, 2008; 51:129-136, doi:10.1016/j.jacc.2007.07.087
© 2008 by the American College of Cardiology Foundation
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Myocardial Gene Expression in Heart Failure Patients Treated With Cardiac Resynchronization Therapy

Responders Versus Nonresponders

Marc Vanderheyden, MD*, Wilfried Mullens, MD, Leen Delrue, PhD, Marc Goethals, MD, Bernard de Bruyne, MD, PhD, William Wijns, MD, PhD, Peter Geelen, MD, PhD, Sofie Verstreken, MD, Francis Wellens, MD and Jozef Bartunek, MD, PhD

Cardiovascular Center, Molecular Cardiology Unit and Cardiovascular Research Center, Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium.


Figure 1
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Figure 1 LV Endomyocardial Expression of Functional and Contractile Genes

Left ventricular (LV) endomyocardial expression of functional and contractile genes at baseline (open bars) and at 4-month follow-up (solid bars) in responders and nonresponders. Data are normalized for glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and expressed as relative units. {alpha}-MHC = {alpha}-myosin heavy chain; β-MHC = β-myosin heavy chain; BNP = brain natriuretic peptide; PLN = phospholamban; SERCA = sarcoplasmic reticulum calcium ATPase 2{alpha}.

 

Figure 2
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Figure 2 LV Endomyocardial Gene Expression of BNP Gene

The LV endomyocardial gene expression of BNP gene at baseline (open bars) and at 4-month follow-up (solid bars) in responders and nonresponders. Data are normalized for GAPDH and expressed as relative units. Abbreviations as in Figure 1.

 




 
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