Effects of Exercise Training on Myocardial Energy Metabolism and Ventricular Function Assessed by Quantitative Phosphorus-31 Magnetic Resonance Spectroscopy and Magnetic Resonance Imaging in Dilated Cardiomyopathy
Meinrad Beer, MD*,*,
Doris Wagner, MD ,
Jonathan Myers, PhD ,
Jörn Sandstede, MD*,
Herbert Köstler, PhD*,
Dietbert Hahn, MD*,
Stefan Neubauer, MD, FRCP and
Paul Dubach, MD
* Institut für Röntgendiagnostik, Universität Würzburg, Würzburg, Germany
Medizinische Klinik Kantonsspital Chur, Chur, Switzerland
Palo Alto Veterans Affairs Medical Center and Stanford University, Palo Alto, California
Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford University, Oxford, United Kingdom.
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Figure 1 Change in PCr Concentrations During Follow-Up
(A) Control and (B) exercise group. The blue lines represent single patients. The green dotted line represents the mean of the respective patient group. Black bars located on the left as well as the right side of the single values show the SD at baseline (left) and at 8-month follow-up (right). PCr = phosphocreatine; 0 = baseline examination; 8 = 8-month follow-up.
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Figure 2 Phosphorus-31 Spectra and Magnetic Resonance Images of a 64-Year-Old Male Patient of the Control Group
Almost completely unchanged morphologic (mass), functional (ejection fraction [EF]), and metabolic (phosphocreatine [PCr] and adenosine triphosphate [ATP] concentrations) parameters during follow-up. The black line with a fixed starting point at the peak of the PCr signal of the baseline examination demonstrates the unchanged PCr concentration during follow-up. LV = left ventricular.
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Figure 3 Phosphorus-31 Spectra and Magnetic Resonance Images of a 35-Year-Old Male Patient of the Exercise Group
Improvement of morphologic (mass), functional (EF), and metabolic (PCr and ATP concentrations) parameters during follow-up. The black line with a fixed starting point at the peak of the PCr signal of the baseline examination demonstrates the tendency toward increasing PCr concentrations during follow-up. Abbreviations as in Figure 2.
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