Plasma N-Terminal B-Type Natriuretic Peptide as an Indicator of Long-Term Survival After Acute Myocardial Infarction: Comparison With Plasma Midregional Pro-Atrial Natriuretic PeptideThe LAMP (Leicester Acute Myocardial Infarction Peptide) Study
Sohail Q. Khan, MB*,*,
Onkar Dhillon, MB*,
Dominic Kelly, MB*,
Iain B. Squire, MD*,
Joachim Struck, PhD ,
Paulene Quinn, MPhil*,
Nils G. Morgenthaler, MD,
Andreas Bergmann, PhD,
Joan E. Davies, PhD* and
Leong L. Ng, MD*
* University of Leicester, Department of Cardiovascular Sciences, Clinical Sciences Building, Leicester Royal Infirmary, Leicester, United Kingdom
Research Department, BRAHMS Aktiengesellschaft, Hennigsdorf, Germany.
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Figure 1 Daily Peptide Sampling and Box Plots
(A) Patient plot for 60 patients. Changes in plasma midregional proatrial natriuretic peptide (MR-proANP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in 60 individual patients within the first 5 days after acute myocardial infarction. (B) Midregional proatrial natriuretic peptide and NT-proBNP box plots. Median and interquartile range of plasma peptide levels in the 132 patients with serial sampling data.
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Figure 3 Kaplan-Meier Survival Curves
Event rate (death) in patients grouped according to quartiles of plasma MR-proANP or NT-proBNP (1 = lowest quartile, 4 = highest quartile). Abbreviations as in Figure 1.
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Figure 4 Combined Kaplan-Meier Survival Curve
Midregional proatrial natriuretic peptide levels (highest quartile vs. lower 3 quartiles) predicting the primary end point of death, in patients stratified by NT-proBNP (highest quartile vs. lower 3 quartiles). Abbreviations as in Figure 1.
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