Acute Onset Human Atrial Fibrillation Is Associated With Local Cardiac Platelet Activation and Endothelial Dysfunction
Joseph G. Akar, MD, PhD*,
Walter Jeske, PhD and
David J. Wilber, MD
Cardiovascular Institute, Loyola University Medical Center, Maywood, Illinois.
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Figure 1 Local Cardiac Platelet Activation
Local cardiac platelet activation increased significantly after 15 min of atrial fibrillation (AF), but did not change after 15 min of atrial pacing. Solid bars = baseline; open bars = 15 min.
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Figure 2 Peripheral Platelet Activation
Peripheral platelet activation did not change following 15 min of either atrial fibrillation (AF) or atrial pacing. Solid bars = baseline; open bars = 15 min.
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Figure 3 Changes in Cardiac Thrombin Generation Following AF
(A) Cardiac thrombinantithrombin complex (TAT) measured at baseline, after 15 min of atrial fibrillation (AF), and following ablation. Cardiac TAT levels increased following AF but returned to baseline at the end of the procedure due to administration of intravenous heparin. (B) Changes in local cardiac prothrombin fragment 1.2 (F1.2) as described above.
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