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Effects of a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor, Fluvastatin, on Coronary Spasm After Withdrawal of Calcium-Channel Blockers

Hirofumi Yasue, MD^_*,_*, Yuji Mizuno, MD^_*, Eisaku Harada, MD^_*, Teruhiko Itoh, MD^_*, Hitoshi Nakagawa, MD^_*, Masafumi Nakayama, MD, Hisao Ogawa, MD, Shinji Tayama, MD, Takasi Honda, MD, Seiji Hokimoto, MD, Shuichi Ohshima, MD, Youichi Hokamura, MD^||, Kiyotaka Kugiyama, MD^¶, Minoru Horie, MD^#, Michihiro Yoshimura, MD^_**, Masaki Harada, MD, Shiroh Uemura, MD, Yoshihiko Saito, MD for the SCAST (Statin and Coronary Artery Spasm Trial) Investigators

^_* Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute, Kumamoto, Japan
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Division of Cardiology, Cardiovascular Center, Saiseikai Kumamoto Hospital, Kumamoto, Japan
Division of Cardiology, Kumamoto Central Hospital, Kumamoto, Japan
^|| Division of Cardiology, Kumamoto City Hospital, Kumamoto, Japan
^¶ Second Department of Internal Medicine, Yamanashi University School of Medicine, Yamanashi, Japan
^# Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Shiga, Japan
^_** Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
First Department of Internal Medicine, Nara Medical University, Nara, Japan.

View larger version (35K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Statin and ACh-Induced Coronary Spasm Number of patients with acetylcholine (Ach)-induced coronary spasm at baseline (blue bars) and after 6 months (orange bars) of treatment in the statin group and nonstatin group.

View larger version (12K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Coronary Artery Diameter Change to ACh Injection Response of coronary artery diameter to intracoronary injection of acetylcholine (ACh) (50 µg) at baseline and after 6 months of treatment at the spasm segment (left) and the nonspasm segment (right) in the statin group (orange; n = 63) and nonstatin (blue; n = 66) group.