This Article Abstract Full Text Full Text (PDF) View Online Appendix-Author Disclosure View Cardiosource Slide Set Correction (v51,p2197) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (10) Citing Articles via Google Scholar Google Scholar Articles by White, H. D. Articles by Stone, G. W. Search for Related Content PubMed PubMed Citation Articles by White, H. D. Articles by Stone, G. W. Related Collections Related Article

Safety and Efficacy of Switching From Either Unfractionated Heparin or Enoxaparin to Bivalirudin in Patients With Non–ST-Segment Elevation Acute Coronary Syndromes Managed With an Invasive Strategy

Results From the ACUITY (Acute Catheterization and Urgent Intervention Triage strategY) Trial

Harvey D. White, DSc, FACC^_*,_*, Derek P. Chew, MBBS, MPH, James W. Hoekstra, MD, Chadwick D. Miller, MD, Charles V. Pollack, Jr, MD, Frederick Feit, MD^||, A. Michael Lincoff, MD, FACC^¶, Michel Bertrand, MD, FACC^#, Stuart Pocock, PhD^_**, James Ware, PhD, E. Magnus Ohman, MD, FACC, Roxana Mehran, MD, FACC and Gregg W. Stone, MD, FACC^||||

^_* Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand
Department of Cardiology, Flinders Medical Centre, Adelaide, Australia
Department of Emergency Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina
Department of Emergency Medicine, University of Pennsylvania Health System, Philadelphia, Pennsylvania
^|| New York University School of Medicine, New York, New York
^¶ Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio
^# Lille Heart Institute, Lille, France
^_** London School of Hygiene and Tropical Medicine, London, United Kingdom
Harvard School of Public Health, Boston, Massachusetts
Duke University Medical Center, Durham, North Carolina
Department of Medicine, Columbia University Medical Center, New York, New York
^|||| Cardiovascular Research Foundation, New York, New York.

View larger version (14K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Flow of ACUITY Trial and Patients Switched Enrollment and randomization to consistent therapy, either unfractionated heparin (UFH) or enoxaparin (Enox), or switch (at the time of randomization) to bivalirudin (Biv) from either UFH or Enox. Naive patients are those who received no antithrombin therapy before randomization. *Patients were also excluded if they did not receive the randomization drug; the administration of the randomization drug was after angiography or they received both UHF and Enox before randomization. ACUITY = Acute Catheterization and Urgent Intervention Triage strategY; GP = glycoprotein.

View larger version (27K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Outcomes of Patients Switched Comparison of patients randomized to bivalirudin versus UFH/Enox by prior antithrombin therapy. CI = confidence interval; RR = relative risk; other abbreviations as in Figure 1.