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J Am Coll Cardiol, 2008; 51:1455-1462, doi:10.1016/j.jacc.2007.11.074
© 2008 by the American College of Cardiology Foundation
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A Randomized Comparison of Triple-Site Versus Dual-Site Ventricular Stimulation in Patients With Congestive Heart Failure

Christophe Leclercq, MD, PhD*,*, Fredrik Gadler, MD, PhD{dagger}, Wolfgang Kranig, MD{ddagger}, Sue Ellery, MD§, Daniel Gras, MD||, Arnaud Lazarus, MD, Jacques Clémenty, MD#, Eric Boulogne, MSc**, Jean-Claude Daubert, MD* for the TRIP-HF (Triple Resynchronization In Paced Heart Failure Patients) Study Group

* CHU Pontchaillou, Rennes, France
{dagger} Karolinska Hospital, Stockholm, Sweden
{ddagger} Schüchtermann-Klinik, Bad Rothenfelde, Germany
§ Eastbourne District General Hospital, Eastbourne, United Kingdom
|| NCN, Nantes, France
InParys, Paris, France
# Hopital Cardiologique, Bordeaux, France
** St. Jude Medical, Zaventem, Belgium.


Figure 1
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  		Figure 1 Calculation of the Z Ratio From Doppler Echocardiography

ECG = electrocardiogram; Z ratio = (left ventricular ejection time + left ventricular filling time)/RR interval.

 

Figure 2
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  		Figure 2 Enrollment, Randomization, and Outcomes of Enrolled Patients, Up to 9 Months of Follow-Up, in Each Study Group

2V = dual-site; 3V = triple-site.

 

Figure 3
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  		Figure 3 Representative Frontal Roentgenographic View of the Leads of a Triple-Site, Biventricular Stimulation System

 

Figure 4
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  		Figure 4 Evolution of Mean Z Ratio Between Patient Enrollment and End of Follow-Up in Each Study Group

In both groups, after the stabilization phase, the Z ratio increased during the period of triple-site biventricular stimulation, and decreased during dual-site stimulation. Abbreviations as in Figure 2.

 

Figure 5
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  		Figure 5 Evolution of Mean LVEF Between Patient Enrollment and End of Follow-Up in Each Study Group

In both groups, after the stabilization phase, left ventricular ejection fraction (LVEF) increased during the period of triple-site biventricular stimulation and decreased during dual-site stimulation. Abbreviations as in Figure 2.

 

Figure 6
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  		Figure 6 Evolution of Mean LVESV Between Patient Enrollment and End of Follow-Up in Each Study Group

LVESV= left ventricular end-systolic volume; other abbreviations as in Figure 2.

 
 
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