Stem Cell Mobilization by Granulocyte Colony-Stimulating Factor for Myocardial Recovery After Acute Myocardial InfarctionA Meta-Analysis
Dietlind Zohlnhöfer, MD*,*,
Alban Dibra, MD*,
Tobias Koppara, MD*,
Antoinette de Waha, MD*,
Rasmus Sejersten Ripa, MD ,
Jens Kastrup, MD,
Marco Valgimigli, MD, PhD ,
Albert Schömig, MD* and
Adnan Kastrati, MD*
* Deutsches Herzzentrum, Technische Universität München, Munich, Germany
Department of Cardiology, The Heart Centre, University Hospital Rigshospitalet, Copenhagen, Denmark
Cardiovascular Institute, University of Ferrara, Ferrara, Italy.
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Figure 1 The Effect of Stem Cell Mobilization by G-CSF on Change of Left Ventricular Ejection Fraction
Compared with control conventional treatment, stem cell mobilization by G-CSF had no additional beneficial effect on change in left ventricular function at follow-up as shown by the weighted mean difference for change in left ventricular ejection fraction between treatment and control groups in individual trials. FIRSTLINE-AMI = Front-Integrated Revascularization and Stem Cell Liberation in Evolving Acute Myocardial Infarction trial; G-CSF = granulocyte colony-stimulating factor; G-CSF-STEMI = Granulocyte Colony-Stimulating Factor ST-Segment Elevation Myocardial Infarction trial; MAGIC Cell 1 = Myocardial Regeneration and Angiogenesis in Myocardial Infarction with G-CSF and Intra-Coronary Stem Cell Infusion 1 trial; REVIVAL-2 = Regenerate Vital Myocardium by Vigorous Activation of Bone Marrow Stem Cells trial; STEMMI = Stem Cells in Myocardial Infarction trial.
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Figure 2 The Effect of G-CSF on Left Ventricular Ejection Fraction at Follow-Up
Compared with control groups, G-CSF had no beneficial effect on left ventricular function at follow-up as shown by the weighted mean difference of left ventricular ejection fraction at follow-up between treatment and control groups. Abbreviations as in Figure 1.
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Figure 3 The Effect of Stem Cell Mobilization on Angiographic Restenosis
Stem cell mobilization by G-CSF had no effect on angiographic restenosis rate as shown by the odds ratios for angiographically assessed binary restenosis. Abbreviations as in Figure 1.
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Figure 4 The Effect of G-CSF on Target Vessel Revascularization
The G-CSF therapy had no effect on target vessel revascularization as shown by the odds ratios for target vessel revascularization. Abbreviations as in Figure 1.
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