Pulse Wave Velocity Is an Independent Predictor of the Longitudinal Increase in Systolic Blood Pressure and of Incident Hypertension in the Baltimore Longitudinal Study of Aging
Samer S. Najjar, MD*,*,
Angelo Scuteri, MD, PhD*, ,
Veena Shetty, MPH*,
Jeanette G. Wright, BA ,
Denis C. Muller, MS,
Jerome L. Fleg, MD, FACC ,
Harold P. Spurgeon, PhD*,
Luigi Ferrucci, MD, PhD and
Edward G. Lakatta, MD*
* Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland
U.O. Geriatria, Instituto Nazionale Ricovero e Cura per Anziani (INRCA), Rome, Italy
Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland
National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland.
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Figure 1 Baseline and Predicted 10-Year Longitudinal Changes in SBP
Baseline and predicted 10-year longitudinal changes in systolic blood pressure (SBP) for men with starting ages 40 years (A) and 70 years (B) whose pulse wave velocity (PWV) at baseline was in the highest versus lowest quartile. For both starting ages, men whose baseline PWV was in the highest quartile showed an accelerated increase in SBP compared with men whose PWV was in the lowest quartile. Quartiles of PWV were separately defined for each age-decade.
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Figure 2 Adjusted Hypertension-Free Survival Curves for Participants Who Were Followed Up for >4.3 Years
All participants were normotensive at 4.3 years and were stratified according to median PWV (5.8 m/s). The curves are adjusted for age, SBP, and high-density lipoprotein (HDL). Abbreviations as in Figure 1.
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