Occurrence and Frequency of Arrhythmias in Hypertrophic Cardiomyopathy in Relation to Delayed Enhancement on Cardiovascular Magnetic Resonance
A. Selcuk Adabag, MD, MS*,*,
Barry J. Maron, MD ,
Evan Appelbaum, MD , ,
Caitlin J. Harrigan, BA,
Jacqueline L. Buros, BA,
C. Michael Gibson, MD, MS,,
John R. Lesser, MD,
Constance A. Hanna, RN,
James E. Udelson, MD||,
Warren J. Manning, MD, and
Martin S. Maron, MD||
* Division of Cardiology, Veterans Affairs Medical Center, Minneapolis, Minnesota
Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, Minnesota
Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts
PERFUSE Core Laboratory and Data Coordinating Center, Harvard Medical School, Boston, Massachusetts
|| Hypertrophic Cardiomyopathy Center, Division of Cardiology, Tufts-New England Medical Center, Boston, Massachusetts.
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Figure 1 Prevalence of Arrhythmias on 24-h Holter ECG With Respect to DE in 177 HCM Patients
DE = delayed enhancement; ECG = electrocardiogram; HCM = hypertrophic cardiomyopathy; NSVT = nonsustained ventricular tachycardia; PVC = premature ventricular contraction; SVT = supraventricular tachycardia.
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Figure 2 ROC Curve to Assess Ability of DE to Discriminate Patients With and Without NSVT on Holter ECG
Area under the curve is 0.77 (95% confidence interval 0.67 to 0.87). ROC = receiver-operating characteristic; other abbreviations as in Figure 1.
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Figure 3 Cardiovascular Magnetic Resonance Image From a 36-Year-Old Hypertrophic Cardiomyopathy Patient
Relatively discrete areas of delayed enhancement (arrows), shown on long-axis (A) and short-axis (B) views, and comprising 4.3% of LV myocardium. In the same patient, a 12-beat run of nonsustained ventricular tachycardia was present on 24-h ambulatory Holter electrocardiogram (C). LA = left atrium; LV = left ventricle; VS = interventricular septum.
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