Ventricular Repolarization Restitution Properties in Patients Exhibiting Type 1 Brugada Electrocardiogram With and Without Inducible Ventricular Fibrillation
Meiso Hayashi, MD,
Seiji Takatsuki, MD,
Pierre Maison-Blanche, MD,
Anne Messali, MD,
Abdeddayem Haggui, MD,
Paul Milliez, MD, PhD,
Antoine Leenhardt, MD and
Fabrice Extramiana, MD, PhD*
Cardiology Department, Lariboisière Hospital, Paris, France.
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Figure 1 Measurement of ARI and Maximum Slope of Repolarization Restitution Curve
(A to C) Unipolar electrograms (EGMs) and their first derivatives (dV/dt) of the S2 at S1 to S2 intervals of 250 ms, 280 ms, and 310 ms with a basic drive cycle length (BCL) of 600 ms are shown. The activation recovery interval (ARI) is the interval between the minimum dV/dt of the QRS and minimum dV/dt of the T wave (between the two dashed lines). (D) The ARI restitution curve is constructed by plotting the ARIs of the S2 against the preceding diastolic intervals. The least-squares linear fit to the 40-ms diastolic interval with the maximum slope is shown. A, B, and C of the curve correspond to the ARIs in A, B, and C, respectively.
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Figure 2 Comparison of Maximum ARI Restitution Slopes
The maximum activation recovery interval (ARI) restitution slopes at each of the 3 basic drive cycle lengths (BCLs) in the right ventricular apex (A) and outflow tract (B) are compared between the patients with (filled circles) and without inducible ventricular fibrillation (unfilled circles). The number written in the circle corresponds to the patient number in Table 1. The dashed line indicates the ARI of the unity.
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