Prolonged Signal-Averaged P-Wave Duration as an Intermediate Phenotype for Familial Atrial Fibrillation
Dawood Darbar, MD, FACC*,*,
Amanda Hardy, RN*,
Jonathan L. Haines, PhD and
Dan M. Roden, MD, FACC
* Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee
Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, Tennessee
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee.
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Figure 1 Pedigree and Haplotypes for Family VAF-1
Filled symbols indicate individuals with atrial fibrillation (AF), square or round dashed symbols indicate obligate carriers, and diagonal lines indicate deceased individuals. Proband is indicated by the arrow. Underlined numbers indicate unaffected individuals used in linkage analyses. Results of genotypic analysis are shown for markers D5S2088, D5S406, D52054, D5635, D5807, and D5S1486 below each individual. The vertical black line to the left of some series of numbers indicates disease haplotype. One consanguineous marriage is indicated by an equals sign. VAF = Vanderbilt atrial fibrillation.
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Figure 2 Ideogram of Chromosome 5 With Giemsa Banding Patterns and Localization of the AF Locus
Genetic map with chromosome 5p15 markers; location of putative AF gene is shown on the right. AF = atrial fibrillation.
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Figure 3 Representative Tracings of Signal-Averaged P-Wave Duration
This patient (II:13) had no history or symptoms of AF, did not carry the AF haplotype, and had a normal P-wave duration (top). A patient (II:20) with AF and the disease haplotype who had prolonged SA P-wave duration (bottom). AF = atrial fibrillation.
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