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Randomized Controlled Trial of an Implantable Continuous Hemodynamic Monitor in Patients With Advanced Heart Failure

The COMPASS-HF Study

Robert C. Bourge, MD^_*,1,_*, William T. Abraham, MD, FACC^,2, Philip B. Adamson, MD, FACC^,3, Mark F. Aaron, MD^,4, Juan M. Aranda, Jr, MD^||,5, Anthony Magalski, MD^¶, Michael R. Zile, MD^#,6, Andrew L. Smith, MD, FACC^_**,7, Frank W. Smart, MD^,8, Mark A. O’Shaughnessy, MD, Mariell L. Jessup, MD^,9, Brandon Sparks, MS^||||,10, David L. Naftel, PhD^_*, Lynne Warner Stevenson, MD^¶¶,11 on behalf of the COMPASS-HF Study Group

^_* Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama
Division of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio
Oklahoma Heart Hospital, Oklahoma City, Oklahoma
Tennessee Cardiovascular Research Institute at St. Thomas Hospital, Nashville, Tennessee
^|| Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida
^¶ Mid-America Heart Institute, Kansas City, Missouri
^# Medical University of South Carolina, Charleston, South Carolina
^_** Crawford Long Hospital/Emory University Hospital, Atlanta, Georgia
Morristown Memorial Hospital, Morristown, New Jersey
Parkview Memorial, Fort Wayne, Indiana
Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
^|||| Medtronic, Inc., Minneapolis, Minnesota
^¶¶ Brigham and Women’s Hospital, Boston, Massachusetts.

View larger version (45K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Two Trends Available on the Chronicle Web Site One-month trends of right ventricular (RV) systolic and estimated pulmonary artery diastolic (ePAD) pressures.

View larger version (21K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Patient Enrollment and Disposition Flow chart details the patient enrollment in the study. LVEF = left ventricular ejection fraction.

View larger version (16K): [in this window] [in a new window] [Download PPT slide]   Figure 3 Distribution of All Heart Failure–Related Events Event rates were compared with a negative binomial regression model.

View larger version (21K): [in this window] [in a new window] [Download PPT slide]   Figure 4 Kaplan-Meier Curves of Survival Free From an HF-Related Hospitalization Hazard ratios (HRs) are from a Cox proportional hazards regression model. HF = heart failure.