Association of Atrial Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activity With the Development of Atrial Fibrillation After Cardiac Surgery
Young M. Kim, BSc*,1,
Hassan Kattach, MRCS ,
Chandi Ratnatunga, FRCS,
Ravi Pillai, FRCS,
Keith M. Channon, MD, FRCP*,2 and
Barbara Casadei, MD, DPhil, FRCP*,2,*
* University Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
Department of Cardiothoracic Surgery, John Radcliffe Hospital, Oxford, United Kingdom.
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Figure 1 Basal and NADPH-Stimulated Superoxide Production
Box plots of basal and nicotinamide adenine dinucleotide phosphate (NADPH)-stimulated superoxide production from right atrial appendage homogenates of patients who remained in sinus rhythm (SR) (n = 99) and those who developed atrial fibrillation (AF) post-operatively (n = 71). The difference in basal superoxide production between SR and AF patients did not quite reach statistical significance (p = 0.07); however, NADPH-stimulated superoxide production was significantly greater in patients who developed AF in the post-operative period (*p < 0.0001). RLU = relative light units.
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Figure 2 Plasma Levels of TBARS and Protein Carbonyls PRE and POST Cardiopulmonary Bypass and Reperfusion
Box plots of plasma levels of thiorbabituric acid-reactive substances (TBARS) and protein carbonyl before (PRE) and after (POST) cardiopulmonary bypass and reperfusion in patients who remained in SR (n = 71) and in those who developed AF post-operatively (n = 53). Thiorbabituric acid-reactive substances and protein carbonyls increased significantly after reperfusion (*p < 0.05 vs. PRE for both); however, these markers did not differ between patients who developed AF versus those who remained in SR. Abbreviations as in Figure 1.
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