Metabolic Effects of Weight Loss on a Very-Low-Carbohydrate Diet Compared With an Isocaloric High-Carbohydrate Diet in Abdominally Obese Subjects
Jeannie Tay, BNutrDiet (Hons)*, ,
Grant D. Brinkworth, PhD*,*,
Manny Noakes, PhD*,
Jennifer Keogh, MSc* and
Peter M. Clifton, PhD*
* Commonwealth Scientific and Industrial Research Organisation–Human Nutrition, Adelaide, Australia
Department of Nutrition and Dietetics, Flinders University, Adelaide, Australia.
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Figure 2 Plasma Ketone Concentrations Before and After Intervention
Ketone concentration at baseline and after 8 and 24 weeks of energy restriction with an VLCHF diet (n = 45) or an HCLF diet (n = 43). *Significant time by diet interaction between the groups (P<0.001) by repeated measures analysis of variance. p < 0.001,  p = 0.01 significantly greater than HCLF by post-hoc comparisons at each time point with Bonferonni adjustment for 3 comparisons. Abbreviations as in Figure 1.
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Figure 3 Body Weight Before and After Intervention
Body weight at baseline and after 24 weeks of energy restriction consumption of an VLCHF diet (n = 45) or an HCLF diet (n = 43). Both diets significantly different (p < 0.001) from baseline (time effect). There was no significant time by diet interaction (p > 0.05) over 24 weeks by repeated-measures analysis of variance. Abbreviations as in Figure 1.
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