Statins for Secondary Prevention in Elderly PatientsA Hierarchical Bayesian Meta-Analysis
Jonathan Afilalo, MD*,
Gustavo Duque, MD, PhD*, ,
Russell Steele, PhD ,
J. Wouter Jukema, MD, PhD ,
Anton J.M. de Craen, PhD|| and
Mark J. Eisenberg, MD, MPH*,¶,1,*
* Department of Medicine, Sir Mortimer B. Davis Jewish General Hospital, McGill University, Montreal, Canada
Division of Geriatrics and Bloomfield Center for Aging Research, Sir Mortimer B. Davis Jewish General Hospital, McGill University, Montreal, Canada
Department of Mathematics and Statistics, McGill University, Montreal, Canada
Division of Cardiology, Leiden University Medical Center, Leiden, the Netherlands
|| Division of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands
¶ Divisions of Cardiology and Clinical Epidemiology, Sir Mortimer B. Davis Jewish General Hospital, McGill University, Montreal, Canada.
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Figure 2 Bayesian Forest Plot for All-Cause Mortality
Statin therapy reduced the incidence of all-cause mortality by 22% over 5 years as compared to placebo. The posterior median estimate of the number need to treat was 28.
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Figure 3 Bayesian Forest Plot for Coronary Heart Disease Mortality
Statin therapy reduced the incidence of coronary heart disease mortality by 30% over 5 years as compared to placebo. The posterior median estimate of the number need to treat was 34.
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Figure 4 Bayesian Forest Plot for Nonfatal Myocardial Infarction
Statin therapy reduced the incidence of nonfatal myocardial infarction by 26% over 5 years as compared to placebo. The posterior median estimate of the number need to treat was 38.
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Figure 5 Bayesian Forest Plot for Revascularization
Statin therapy reduced the need for revascularization (percutaneous coronary intervention or aortocoronary bypass surgery) by 30% over 5 years as compared to placebo. The posterior median estimate of the number need to treat was 24.
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Figure 6 Bayesian Forest Plot for Stroke
Statin therapy reduced the incidence of stroke by 25% over 5 years as compared to placebo. The posterior median estimate of the number need to treat was 58.
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