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J Am Coll Cardiol, 2007; 50:892-896, doi:10.1016/j.jacc.2007.05.024 (Published online 10 August 2007).
© 2007 by the American College of Cardiology Foundation
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18Fluorodeoxyglucose Positron Emission Tomography Imaging of Atherosclerotic Plaque Inflammation Is Highly Reproducible

Implications for Atherosclerosis Therapy Trials

James H.F. Rudd, MD, PhD*,1,*, Kelly S. Myers, BS*, Sameer Bansilal, MD{dagger}, Josef Machac, MD{ddagger}, Ash Rafique, BS{ddagger}, Michael Farkouh, MD, MSc{dagger}, Valentin Fuster, MD, PhD§ and Zahi A. Fayad, PhD, FACC, FAHA*

* Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York
{dagger} Cardiovascular Imaging Clinical Trials Unit, Mount Sinai School of Medicine, New York, New York
{ddagger} Division of Nuclear Medicine, Department of Radiology, Mount Sinai School of Medicine, New York, New York
§ The Zena and Michael A. Wiener Cardiovascular Institute and Marie-Josee and Henry R. Kravis Cardiovascular Health Center, Mount Sinai School of Medicine, New York, New York.


Figure 1
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  		Figure 1 Mean TBR Values at First and Second Scan

Error bars indicate standard deviation. Little spontaneous change in tissue-to-background ratio (TBR) values between the two scans is noted. *p < 0.05 for the TBR of both left and right carotid artery compared with the TBR of all aortic regions. Abd = abdominal; Asc = ascending; Desc = descending.

 

Figure 2
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  		Figure 2 Carotid and Aortic PET/CT Images Over 2 Weeks

(A) Axial images from scan 1 and 2 of one subject’s carotid artery. Computed tomography (CT) (left), positron emission tomography (PET) (middle), and fused PET/CT (right) with arrows indicating similar 18fluorodeoxyglucose (FDG) uptake in the right carotid artery at both time points. (B) Sagittal images from scan 1 and 2 of another subject’s aorta. CT (left), PET (middle), and fused PET/CT (right) with arrows indicating similar FDG uptake in the aortic arch and descending aorta at both time points.

 

Figure 3
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  		Figure 3 Bland-Altman Plots of Interobserver, Intraobserver, and Interscan Variability

(A) Interobserver, (B) intraobserver, and (C) interscan variability. The dashed line is the mean difference between the 2 scans, while the limits of agreement are drawn as solid lines (mean difference ± 2 SD). TBR = tissue-to-background ratio.

 

Figure 4
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  		Figure 4 Sample Size Estimates Based on Drug Efficacy

The number of subjects needed in trials using 18fluorodeoxyglucose positron emission tomography is shown for several levels of drug effect.

 




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Copyright © 2007 by the American College of Cardiology Foundation.