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Characteristics, Treatments, and Outcomes of Patients With Preserved Systolic Function Hospitalized for Heart Failure

A Report From the OPTIMIZE-HF Registry

Gregg C. Fonarow, MD, FACC^_*,_*, Wendy Gattis Stough, PharmD, William T. Abraham, MD, FACC, Nancy M. Albert, PhD, RN, Mihai Gheorghiade, MD, FACC^||, Barry H. Greenberg, MD, FACC^¶, Christopher M. O’Connor, MD, FACC^#, Jie Lena Sun, MS^_**, Clyde W. Yancy, MD, FACC, James B. Young, MD, FACC for the OPTIMIZE-HF Investigators and Hospitals

^_* Department of Medicine, UCLA Medical Center, Los Angeles, California
Department of Medicine, Duke University Medical Center, Durham, North Carolina, and Department of Clinical Research, Campbell University School of Pharmacy, Research Triangle Park, North Carolina
Division of Cardiology, Ohio State University, Columbus, Ohio
George M. and Linda H. Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Cleveland, Ohio
^|| Division of Cardiology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois
^¶ Department of Medicine, USCD Medical Center, San Diego, California
^# Division of Cardiology, Duke University Medical Center/Duke Clinical Research Institute, Durham, North Carolina
^_** Duke Clinical Research Institute, Durham, North Carolina
Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas (formerly Department of Medicine, University of Texas, Southwestern Medical Center, Dallas, Texas)
Department of Cardiovascular Medicine, Heart Failure Section, Cleveland Clinic Foundation, Cleveland, Ohio.

View larger version (30K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Distribution of Patients’ LVEFs Histogram of left ventricular ejection fraction (LVEF) in patients hospitalized with a primary discharge diagnosis of heart failure.

View larger version (14K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Survival After Hospital Discharge in Patients With LVSD Compared With PSF Kaplan-Meier survival curves after hospital discharge in patients with left ventricular systolic dysfunction (LVSD) compared with patients with preserved systolic function (PSF) in the follow-up cohort.

View larger version (32K): [in this window] [in a new window] [Download PPT slide]   Figure 3 Discharge Medications and Application of Performance Measures in Patients With LVSD Compared With PSF Note that only discharge instructions, smoking cessation counseling, and anticoagulation for AF are current American College of Cardiology/American Heart Association performance measures for which heart failure patients with PSF are included. ACE = angiotensin-converting enzyme inhibitor; AF = atrial fibrillation; Ald Ant = aldosterone antagonist; ARB = angiotensin receptor blocker; other abbreviations as in Figure 2.