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J Am Coll Cardiol, 2007; 50:607-613, doi:10.1016/j.jacc.2007.05.014 (Published online 29 July 2007).
© 2007 by the American College of Cardiology Foundation
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Measurement of the Interleukin Family Member ST2 in Patients With Acute Dyspnea

Results From the PRIDE (Pro-Brain Natriuretic Peptide Investigation of Dyspnea in the Emergency Department) Study

James L. Januzzi, Jr, MD FACC*,1,2,*, W. Frank Peacock, MD{dagger},1, Alan S. Maisel, MD, FACC{ddagger},1,2, Claudia U. Chae, MD, MPH, FACC*, Robert L. Jesse, MD, FACC§,1, Aaron L. Baggish, MD*, Michelle O’Donoghue, MD*, Rahul Sakhuja, MD*, Annabel A. Chen, MD*, Roland R.J. van Kimmenade, MD||, Kent B. Lewandrowski, MD*, Donald M. Lloyd-Jones, MD, MSc, FACC and Alan H.B. Wu, PhD#,1

* Department of Medicine and Laboratory Medicine, Massachusetts General Hospital, Boston, Massachusetts
{dagger} Department of Emergency Medicine, Cleveland Clinic Foundation, Cleveland, Ohio
{ddagger} Department of Medicine, University of California, San Diego, California
# Department of Laboratory Medicine, University of California, San Francisco, California
§ Department of Medicine, Virginia Commonwealth University, Richmond, Virginia
|| Department of Medicine, University Hospital Maastricht, Maastricht, the Netherlands
Department of Preventive Medicine and Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois.


Figure 1
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  		Figure 1 ST2 Concentrations at Presentation as a Function of Survival at 1 Year

Medians are depicted; boxes represent the 25th and 75th percentile, whereas whiskers represent the 5th and 95th percentile.

 

Figure 2
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  		Figure 2 Rates of Death at 1 Year as a Function of ST2 Decile in Dyspneic Patients

Rates of death at 1 year as a function of ST2 concentrations in dyspneic patients.

 

Figure 3
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  		Figure 3 Receiver-Operating Characteristic Analysis for ST2 and Death at 1 Year

Receiver operating characteristic analysis with area under the curve (AUC) demonstrated for ST2 and death at 1 year after presentation with dyspnea. Candidate cut-points for ST2 are depicted. CI = confidence interval.

 

Figure 4
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  		Figure 4 Hazard Curves Depicting the Rates of Death From Presentation to 1 Year of Follow-Up

Among dyspneic patients with ST2 concentrations ≥0.20 ng/ml, a high rate of mortality was noted among those (A) with and (B) without acute heart failure (all log-rank p values <0.001).

 

Figure 5
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  		Figure 5 Mortality Rates at 1 Year as a Function of ST2 and NT-proBNP Concentrations

Mortality rates at 1 year as a function of ST2 and amino-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations among (A) dyspneic patients with and without acute heart failure (HF) (n = 593) as well as (B) those with acute HF (n = 208).

 




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