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Aldosterone Receptor Antagonism Induces Reverse Remodeling When Added to Angiotensin Receptor Blockade in Chronic Heart Failure

Anna K.Y. Chan, MB, MRCP^_*, John E. Sanderson, MD, FRCP, FACC^_*,_*, Tian Wang, PhD^_*, Wynnie Lam, FRCR, Gabriel Yip, MD^_*, Mei Wang, MD, PhD^_*, Yat-Yin Lam, MB, MRCP^_*, Yan Zhang, PhD^_*, Leata Yeung, RN, MPhil^_*, Eugene B. Wu, MD^_*, Wilson W.M. Chan, MD^_*, John T.H. Wong, MB, MRCP^_*, Nina So, FRCR and Cheuk-Man Yu, MD, FRCP^_*

^_* Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China
Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China.

View larger version (21K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Flow Chart Depicting the Design of the Study ACEI = angiotensin-converting enzyme inhibition; CMR = cardiac magnetic resonance imaging; EF = ejection fraction; ETT = exercise treadmill time; NYHA = New York Heart Association.

View larger version (7K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Serial Changes of LVEF, LVEDVI, and LVESVI by CMR CMR = cardiac magnetic resonance imaging; LVEDVI = left ventricular end-diastolic volume index; LVEF = left ventricular ejection fraction; LVESVI = left ventricular end-systolic volume index.