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J Am Coll Cardiol, 2007; 50:584-590, doi:10.1016/j.jacc.2007.03.058 (Published online 29 July 2007).
© 2007 by the American College of Cardiology Foundation
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Volume-to-Creatinine Clearance Ratio

A Pharmacokinetically Based Risk Factor for Prediction of Early Creatinine Increase After Percutaneous Coronary Intervention

Warren K. Laskey, MD, FACC*,*, Charles Jenkins, MD*, Faith Selzer, PhD{dagger}, Oscar C. Marroquin, MD, FACC{dagger}, Robert L. Wilensky, MD, FACC{ddagger}, Ruchira Glaser, MD, FACC{ddagger}, Howard A. Cohen, MD, FACC§, David R. Holmes, Jr, MD, FACC|| for the NHLBI Dynamic Registry Investigators

* University of New Mexico School of Medicine, Albuquerque, New Mexico
{dagger} University of Pittsburgh, Pittsburgh, Pennsylvania
{ddagger} University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
§ Lenox Hill Heart and Vascular Institute, New York, New York
|| Mayo Clinic, Rochester, Minnesota.


Figure 1
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  		Figure 1 Relationship Between V/CrCl Ratio and Early Creatinine Increase

The association between ratio of the volume of contrast media to the creatinine clearance (V/CrCl) and the percentage of patients with an early abnormal increase in creatinine after percutaneous coronary intervention (PCI) was highly significant (p < 0.001 overall and for trend).

 

Figure 2
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  		Figure 2 Distribution of V/CrCl Ratio in Current Study

The distributions of ratio of the volume of contrast media to the creatinine clearance (V/CrCl) values in patients with and without an early abnormal increase in creatinine were significantly different (p < 0.001). CAN = contrast media-associated nephrotoxicity.

 

Figure 3
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  		Figure 3 Receiver-Operator Characteristics Curve

Receiver-operator characteristics analysis indicated an optimum cutoff value for ratio of the volume of contrast media to the creatinine clearance (V/CrCl) of 3.7 (*). The C-statistic was 0.69.

 




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Copyright © 2007 by the American College of Cardiology Foundation.