JACC
HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK
QUICK SEARCH:   [advanced]


     

J Am Coll Cardiol, 2007; 50:335-343, doi:10.1016/j.jacc.2007.03.045 (Published online 6 July 2007).
© 2007 by the American College of Cardiology Foundation
This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (2)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ogawa, M.
Right arrow Articles by Chen, P.-S.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Ogawa, M.
Right arrow Articles by Chen, P.-S.

Left Stellate Ganglion and Vagal Nerve Activity and Cardiac Arrhythmias in Ambulatory Dogs With Pacing-Induced Congestive Heart Failure

Masahiro Ogawa, MD, PhD*, Shengmei Zhou, MD*, Alex Y. Tan, MD*, Juan Song, PhD*, Ghassan Gholmieh, MD, PhD{dagger}, Michael C. Fishbein, MD, FACC{ddagger}, Huai Luo, MD*, Robert J. Siegel, MD, FACC*, Hrayr S. Karagueuzian, PhD*, Lan S. Chen, MD{dagger}, Shien-Fong Lin, PhD* and Peng-Sheng Chen, MD, FACC*,*

* Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California
{dagger} Division of Neurology, Department of Pediatrics, Children’s Hospital, Los Angeles and USC Keck School of Medicine, Los Angeles, California
{ddagger} Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California.


Figure 1
View larger version (58K):
[in this window]
[in a new window]
[Download PPT slide]
  		Figure 1 Examples of Autonomic Nervous System Activity From Dog #1

(A) Simultaneous stellate ganglion nerve activity (SGNA) and vagal nerve activity (VNA) discharges cause bradycardia at baseline. (B) Similar phenomenon after the induction of congestive heart failure (CHF). (C) A brief period of sympathovagal discharge (between first and second arrows) induced long paroxysmal atrial tachycardia during CHF. ECG = electrocardiography.

 

Figure 2
View larger version (52K):
[in this window]
[in a new window]
[Download PPT slide]
  		Figure 2 LABDA and HASDA

(A) High amplitude spike discharge activity (HASDA) induced couplets and abruptly increased heart rate 6 days after cessation of rapid pacing in dog #2. (B) Low amplitude burst discharge activity (LABDA) episodes associated with isolated premature ventricular contraction and couplets 1 day after cessation of rapid pacing in dog #3. (C) LABDA episodes associated with isolated premature ventricular contraction and triplets (ventricular tachycardia) 1 day after cessation of rapid pacing in dog #2. Abbreviations as in Figure 1.

 

Figure 3
View larger version (47K):
[in this window]
[in a new window]
[Download PPT slide]
  		Figure 3 HASDA and Premature Contractions

(A) HASDA induced isolated premature atrial contraction 1 day after cessation of rapid pacing in dog #2. (B) HASDA induced isolated premature ventricular contraction 7 days after cessation of rapid pacing in the same dog. Abbreviations as in Figures 1 and 2.

 

Figure 4
View larger version (9K):
[in this window]
[in a new window]
[Download PPT slide]
  		Figure 4 Circadian Variations of HASDA

We manually analyzed the number of high amplitude spike discharge activity (HASDA) episodes at baseline (1 day before commencement of rapid pacing) and during congestive heart failure (CHF) (1 day after cessation of pacing). The data of all dogs were then pooled together. There were circadian variations of HASDA, with peak incidence 7:00 AM to 8:00 AM.

 

Figure 5
View larger version (46K):
[in this window]
[in a new window]
[Download PPT slide]
  		Figure 5 SGNA and Prolonged Sinus Pause

(A) Abrupt termination of LABDA preceded a prolonged sinus pause (PSP) episode. (B) Intermittent LABDA (arrows) associated with intermittently increased heart rate, and a large LABDA (*) induced tachycardia. Sudden SGNA withdrawal resulted in 5.5-s PSP. (C) The data within the dotted line in panel B. Abbreviations as in Figures 1 and 2.

 

Figure 6
View larger version (58K):
[in this window]
[in a new window]
[Download PPT slide]
  		Figure 6 Heart Failure Increases Autonomic Nerve Activity

This figure shows 24-h distributions of integrated SGNA and VNA at baseline and after cessation of rapid pacing in all dogs. Abbreviations as in Figure 1.

 

Figure 7
View larger version (151K):
[in this window]
[in a new window]
[Download PPT slide]
  		Figure 7 Histological Studies

(A and B) Masson’s trichrome stain of sinus node and right atrium, respectively. There was increased fibrosis (blue) in these tissues. The objective was 4x, and the calibration bar is 1 mm. (C and D) TH and ChAT staining, respectively, of the vagal nerves. Arrows point to positively stained structures in brown color. The objective was 10x, and the calibration bar is 0.1 mm.

 




HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK
Copyright © 2007 by the American College of Cardiology Foundation.