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J Am Coll Cardiol, 2007; 50:299-308, doi:10.1016/j.jacc.2007.03.042
© 2007 by the American College of Cardiology Foundation
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Exercise Oscillatory Ventilation May Predict Sudden Cardiac Death in Heart Failure Patients

Marco Guazzi, MD, PhD, FACC*,*, Rosa Raimondo, MD{dagger}, Marco Vicenzi, MD*, Ross Arena, PhD§, Chiara Proserpio, MD{ddagger}, Simona Sarzi Braga, MD{dagger} and Roberto Pedretti, MD{dagger}

* Cardiopulmonary Unit, Cardiology Division, University of Milano, San Paolo Hospital, Milano, Italy
{dagger} Division of Cardiology, IRCCS Salvatore Maugeri Foundation, Scientific Institute of Tradate, Tradate (VA), Italy
{ddagger} Division of Cardiology, University of Insubria, Varese, Italy
§ Virginia Commonwealth University, Richmond, Virginia.


Figure 1
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  		Figure 1 ROC Curves Showing the Ability of Peak VO2 to Predict Overall Mortality, SCD, and Pump Failure Death

For panel A overall mortality: area under the curve 0.71, p < 0.001, 95% confidence interval (CI) 0.61 to 0.81, optimal threshold ≤/>14.4, sensitivity 67, specificity 72. For panel B sudden cardiac death (SCD): area under the curve 0.70, p = 0.006, 95% CI 0.58 to 0.82, optimal threshold ≤/>14.4, sensitivity 65, specificity 71. For panel C cardiac pump failure: area under the curve 0.66, p = 0.03, CI 0.51 to 0.78, optimal threshold ≤/>13, sensitivity 73, specificity 53. ROC = receiver-operating characteristic; VO2 = oxygen uptake.

 

Figure 2
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  		Figure 2 ROC Curves Showing the Ability of VE/VCO2 Slope to Predict Overall Mortality, SCD, and Pump Failure Death

For panel A overall mortality: area under the curve 0.74, p < 0.001, 95% CI 0.61 to 0.81, optimal threshold ≤/>37.0, sensitivity 75, specificity 62. For panel B SCD: area under the curve 0.74, p = 0.002, 95% CI 0.61 to 0.81, optimal threshold ≤/>39.2, sensitivity 81, specificity 53. For panel C cardiac pump failure: area under the curve 0.69, p = 0.01, 95% CI 0.61 to 0.81, optimal threshold ≤/>37.0, sensitivity 72, specificity 65. VE/VCO2 = ventilation/carbon dioxide production; other abbreviations as in Figure 1.

 

Figure 3
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  		Figure 3 ROC Curves Showing the Ability of EOB to Predict Overall Mortality, SCD, and Pump Failure Death

For panel A overall mortality: area under the curve 0.78, p < 0.001, 95% CI 0.61 to 0.81, optimal threshold N/A, sensitivity 78, specificity 73. For panel B SCD: area under the curve 0.87, p < 0.001, 95% CI 0.61 to 0.81, optimal threshold N/A, sensitivity 75, specificity 100. For panel C cardiac pump failure: area under the curve 0.58, p = 0.30, 95% CI 0.61 to 0.81, optimal threshold N/A, sensitivity 69, specificity 47. EOB = exercise oscillatory breathing; other abbreviations as in Figure 1.

 

Figure 4
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  		Figure 4 Overall Cardiac Mortality Kaplan-Meier Plots Relating Survival to EOB, VE/VCO2 Slope, and Peak VO2

Abbreviations as in Figures 1, 2, and 3.

 

Figure 5
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  		Figure 5 SCD Mortality Kaplan-Meier Plots Relating Survival to EOB, VE/VCO2 Slope, and Peak VO2

Abbreviations as in Figures 1, 2, and 3.

 

Figure 6
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  		Figure 6 Pump Failure Mortality Kaplan-Meier Plots Relating Survival to EOB, VE/VCO2 Slope, and Peak VO2

Abbreviations as in Figures 1, 2, and 3.

 




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Copyright © 2007 by the American College of Cardiology Foundation.