Exercise Oscillatory Ventilation May Predict Sudden Cardiac Death in Heart Failure Patients
Marco Guazzi, MD, PhD, FACC*,*,
Rosa Raimondo, MD ,
Marco Vicenzi, MD*,
Ross Arena, PhD ,
Chiara Proserpio, MD ,
Simona Sarzi Braga, MD and
Roberto Pedretti, MD
* Cardiopulmonary Unit, Cardiology Division, University of Milano, San Paolo Hospital, Milano, Italy
Division of Cardiology, IRCCS Salvatore Maugeri Foundation, Scientific Institute of Tradate, Tradate (VA), Italy
Division of Cardiology, University of Insubria, Varese, Italy
Virginia Commonwealth University, Richmond, Virginia.
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Figure 1 ROC Curves Showing the Ability of Peak VO2 to Predict Overall Mortality, SCD, and Pump Failure Death
For panel A overall mortality: area under the curve 0.71, p < 0.001, 95% confidence interval (CI) 0.61 to 0.81, optimal threshold  />14.4, sensitivity 67, specificity 72. For panel B sudden cardiac death (SCD): area under the curve 0.70, p = 0.006, 95% CI 0.58 to 0.82, optimal threshold />14.4, sensitivity 65, specificity 71. For panel C cardiac pump failure: area under the curve 0.66, p = 0.03, CI 0.51 to 0.78, optimal threshold />13, sensitivity 73, specificity 53. ROC = receiver-operating characteristic; VO2 = oxygen uptake.
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Figure 2 ROC Curves Showing the Ability of VE/VCO2 Slope to Predict Overall Mortality, SCD, and Pump Failure Death
For panel A overall mortality: area under the curve 0.74, p < 0.001, 95% CI 0.61 to 0.81, optimal threshold />37.0, sensitivity 75, specificity 62. For panel B SCD: area under the curve 0.74, p = 0.002, 95% CI 0.61 to 0.81, optimal threshold />39.2, sensitivity 81, specificity 53. For panel C cardiac pump failure: area under the curve 0.69, p = 0.01, 95% CI 0.61 to 0.81, optimal threshold />37.0, sensitivity 72, specificity 65. VE/VCO2 = ventilation/carbon dioxide production; other abbreviations as in Figure 1.
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Figure 3 ROC Curves Showing the Ability of EOB to Predict Overall Mortality, SCD, and Pump Failure Death
For panel A overall mortality: area under the curve 0.78, p < 0.001, 95% CI 0.61 to 0.81, optimal threshold N/A, sensitivity 78, specificity 73. For panel B SCD: area under the curve 0.87, p < 0.001, 95% CI 0.61 to 0.81, optimal threshold N/A, sensitivity 75, specificity 100. For panel C cardiac pump failure: area under the curve 0.58, p = 0.30, 95% CI 0.61 to 0.81, optimal threshold N/A, sensitivity 69, specificity 47. EOB = exercise oscillatory breathing; other abbreviations as in Figure 1.
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