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J Am Coll Cardiol, 2007; 50:225-231, doi:10.1016/j.jacc.2007.02.071 (Published online 28 June 2007).
© 2007 by the American College of Cardiology Foundation
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Ventricular Repolarization Dynamicity Provides Independent Prognostic Information Toward Major Arrhythmic Events in Patients With Idiopathic Dilated Cardiomyopathy

Massimo Iacoviello, MD, PhD*,*, Cinzia Forleo, MD, PhD*, Pietro Guida, PhD*, Roberta Romito, MD{dagger}, Antonio Sorgente, MD*, Sandro Sorrentino, PhD*, Silvana Catucci, MD*, Filippo Mastropasqua, MD{ddagger} and Mariavittoria Pitzalis, MD, PhD§

* Institute of Cardiology, University of Bari, Bari, Italy
{dagger} Emergency Cardiology Department, University-Hospital of Bari, Bari, Italy
{ddagger} Division of Cardiology, "S. Maugeri" Foundation, Cassano delle Murge, Italy
§ Division of Cardiology, Department of Internal Medicine, The Brody School of Medicine at East Carolina University, Greenville, North Carolina.


Figure 1
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  		Figure 1 Kaplan-Meier Estimates for Arrhythmia-Free Survival for QTe-Slope >0.19 Versus QTe-Slope ≤0.19

QTe-slope = slope of linear regression analysis of QT end and RR intervals.

 

Figure 2
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  		Figure 2 Kaplan-Meier Curves According to Combinations of LVEF, NSVT, and QTe-Slope

Kaplan-Meier estimates for arrhythmia-free survival for: (A) combinations of left ventricular ejection fraction (LVEF) (≤35% or >35%) and presence or absence of nonsustained ventricular tachycardia (NSVT) (NSVT+ and NSVT–, respectively); (B) combinations of LVEF (≤35% or >35%) and slope of linear regression analysis of QT end and RR intervals (QTe-slope) (>0.19 or ≤0.19); (C) combinations of LVEF >35%, NSVT– and QTe-slope <0.19 (Group A); LVEF >35%, NSVT+ or QTe-slope >0.19 (Group B); LVEF ≤35%, NSVT–, and QTe-slope ≤0.19 (Group C); LVEF ≤35%, NSVT+ or QTe-slope >0.19 (Group D). No differences were observed among survival curves of patients belonging to Group A, B, and C (chi-square 1.36; p = 0.51). Only when Group D patients were included in the analysis did the comparison reach statistical significance (chi-square 20.20; p < 0.0001).

 

Figure 3
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  		Figure 3 Probability of Arrhythmic Events Out to 36 Months in Patients With LVEF <35%

Bar graph illustrating the probability of arrhythmic events at 36 months in patients with LVEF <35% according to the presence or absence of NSVT and QTe-slope above or below median value. The number of patients in each subgroup is reported. Abbreviations as in Figure 2.

 




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Copyright © 2007 by the American College of Cardiology Foundation.