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Comparison of Midregional Pro-Atrial Natriuretic Peptide With N-Terminal Pro-B-Type Natriuretic Peptide in Predicting Survival in Patients With Chronic Heart Failure

Stephan von Haehling, MD^_*,,5,_*, Ewa A. Jankowska, MD, Nils G. Morgenthaler, MD^,1, Corrado Vassanelli, MD^||, Luisa Zanolla, MD^||, Piotr Rozentryt, MD^¶, Gerasimos S. Filippatos, MD^#, Wolfram Doehner, MD, PhD^_*, Friedrich Koehler, MD^_**, Jana Papassotiriou, PhD, Dimitrios T. Kremastinos, MD, PhD^#, Waldemar Banasiak, MD, Joachim Struck, PhD^,1,2, Piotr Ponikowski, MD, PhD, Andreas Bergmann, PhD^,1,2,3 and Stefan D. Anker, MD, PhD^_*,,4

^_* Applied Cachexia Research, Department of Cardiology, Charité Medical School, Berlin, Germany
Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
Cardiology Department, Military Hospital, Wroclaw, Poland
Research Department, B.R.A.H.M.S Aktiengesellschaft, Biotechnology Centre, Hennigsdorf/Berlin, Germany
^|| Department of Biomedical and Surgical Sciences, Section of Cardiology, University of Verona, Verona, Italy
^¶ Third Department of Cardiology, Silesian Center for Heart Disease, Zabrze, Poland
^# Second University Department of Cardiology, Atticon University Hospital, Athens, Greece
^_** Charité Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.

View larger version (22K): [in this window] [in a new window] [Download PPT slide]   Figure 1 MR-proANP and NT-proBNP in the Derivation Cohort Midregional pro-atrial natriuretic peptide (MR-proANP) (left) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) (right) levels according to New York Heart Association (NYHA) functional class in 525 patients with chronic heart failure in the derivation cohort.

View larger version (22K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Survival During Follow-Up Kaplan-Meier survival curves subgrouped according to ascending quartiles of MR-proANP (left) or NT-proBNP (right). Abbreviations as in Figure 1.

View larger version (19K): [in this window] [in a new window] [Download PPT slide]   Figure 3 Sensitivity and Specificity for 24-Month Survival Receiver operating curves for 24-month survival for MR-proANP (blue solid line) and NT-proBNP (red dashed line). Abbreviations as in Figure 1.

View larger version (18K): [in this window] [in a new window] [Download PPT slide]   Figure 4 Detection of MR-proANP Sequence of pro-atrial natriuretic peptide (proANP) used for the detection of MR-proANP and principle of the test, making use of a primary antibody that is coated on a polystyrene tube and a secondary signaling antibody. Abbreviations as in Figure 1.