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Pre-Transplant Toxoplasma gondii Seropositivity Among Heart Transplant Recipients Is Associated With an Increased Risk of All-Cause and Cardiac Mortality

Satish Arora, MD^_*,_*, Pål A. Jenum, MD, PhD^,||, Pål Aukrust, MD, PhD, Halvor Rollag, MD, PhD^,¶, Arne K. Andreassen, MD, PhD^_*, Svein Simonsen, MD, PhD^_*, Einar Gude, MD^_*, Arnt E. Fiane, MD, PhD, Odd Geiran, MD, PhD^,¶ and Lars Gullestad, MD, PhD^_*

^_* Department of Cardiology, Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway
Institute of Medical Microbiology, Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway
Section of Clinical Immunology and Infectious Diseases, Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway
Department of Thoracic and Cardiovascular Surgery, Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway
^|| Department of Microbiology, Central Laboratory, Hospital of Asker and Baerum, Oslo, Norway
^¶ Faculty Division Rikshospitalet, University of Oslo, Oslo, Norway.

View larger version (16K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Survival According to Recipient T. gondii Serostatus at Time of Heart Transplantation Toxoplasma gondii (T. gondii) seropositive recipients had a significantly higher risk of all-cause mortality, and this was predominantly evident in the period beyond 4 years after transplantation.

View larger version (17K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Population Free From Moderate/Severe CAV According to Recipient T. gondii Serostatus Toxoplasma gondii (T. gondii) seropositive recipients had a significantly higher risk of developing advanced CAV. Deaths without development of moderate/severe CAV and patients with only mild CAV are considered as censored. CAV = cardiac allograft vasculopathy.