High Serum Cholesteryl Ester Transfer Rates and Small High-Density Lipoproteins Are Associated With Young Age in Patients With Acute Myocardial Infarction
Marianne Zeller, PhD*,
David Masson, PharmD, PhD ,||,
Michel Farnier, MD, PhD ,
Luc Lorgis, MD ,
Valérie Deckert, PhD,
Jean-Paul Pais de Barros, PhD,
Catherine Desrumaux, PhD,
Pierre Sicard, MSc*,
Jacques Grober, PhD,
Denis Blache, PhD,
Philippe Gambert, MD, PhD,||,
Luc Rochette, PharmD, PhD*,
Yves Cottin, MD, PhD and
Laurent Lagrost, PhD,*
* Laboratory of Cardiovascular and Experimental Physiopathology and Pharmacology, IFR Santé STIC, Dijon, France
INSERM U866, University of Burgundy, Dijon, France
Point Médical, Dijon, France
Department of Cardiology, University Hospital, Dijon, France
|| Department of Medical Biochemistry, University Hospital, Dijon, France.
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Figure 1 The Highest CET Rates Are Found Among the Youngest Patients With First MI
Patients without a history of coronary artery disease (n = 347) were divided into tertiles of both non–high-density lipoprotein-cholesterol (HDL-c) and HDL2b. The highest cholesteryl ester transfer (CET) rate (nmol/ml/h) was observed in patients with the lowest HDL2b levels and the highest non–HDL-c levels. Numbers at the top of each bar represent mean age to first myocardial infarction (MI) (years). The subgroup with the highest CET rate contains the youngest patients, with an 18-year difference from the subgroup with the lowest CET rate (p < 0.001). Non–HDL-c (mg/dl) tertiles: low <141, medium 142 to 180, and high >181. HDL2b (%) tertiles: low <14.48, medium 14.50 to 20.61, and high >20.72.
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