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Prognostic Value of T-Wave Alternans in Patients With Heart Failure Due to Nonischemic Cardiomyopathy

Results of the ALPHA Study

Jorge A. Salerno-Uriarte, MD^_*,_*, Gaetano M. De Ferrari, MD, Catherine Klersy, MD, Roberto F.E. Pedretti, MD, Massimo Tritto, MD^||, Luciano Sallusti, BS^¶, Luigi Libero, MD^#, Giacinto Pettinati, MD^_**, Giulio Molon, MD, Antonio Curnis, MD, Eraldo Occhetta, MD, Fabrizio Morandi, MD^_*, Paolo Ferrero, MD^#, Francesco Accardi, BS^¶ for the ALPHA Study Group Investigators

^_* Dipartimento di Scienze Cardiovascolari, Università degli Studi dell’Insubria, Ospedale di Circolo e Fondazione Macchi, Varese, Italy
Dipartimento di Cardiologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
Servizio di Biometria ed Epidemiologia Clinica, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
Divisione di Cardiologia, IRCCS Fondazione Salvatore Maugeri, Istituto Scientifico, Tradate, Italy
^|| Laboratorio di Elettrofisiologia, Dipartimento di Cardiologia, Istituto Clinico Mater Domini, Castellanza, Italy
^¶ Dipartimento Clinico, Guidant Italia (Boston Scientific Corporation), Milano, Italy
^# Divisione Universitaria di Cardiologia, Università degli Studi di Torino, Azienda Ospedaliera San Giovanni Battista, Torino, Italy
^_** Divisione di Cardiologia, Presidio Ospedaliero F. Ferrari, Casarano, Italy
Divisione di Cardiologia, Ospedale Sacro Cuore, Negrar, Italy
Unità Operativa di Cardiologia, Università degli Studi di Brescia, Spedali Civili, Brescia, Italy
1° Divisione di Cardiologia, Università degli Studi del Piemonte Orientale, Ospedale Maggiore, Novara, Italy.

View larger version (13K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Freedom From Cardiac Death + Life-Threatening Arrhythmias Primary end point: Kaplan-Meier cumulative event-free survival according to T-wave alternans (TWA) test. Patients at risk at selected time points are reported.

View larger version (10K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Freedom From Total Mortality and Arrhythmic Death + Life-Threatening Arrhythmias Secondary end points: (A) Kaplan-Meier cumulative survival (total mortality) and (B) Kaplan-Meier event-free survival (arrhythmic death + life-threatening arrhythmias) according to T-wave alternans (TWA) test.