Impact of Intracoronary Cell Therapy on Left Ventricular Function in the Setting of Acute Myocardial InfarctionA Collaborative Systematic Review and Meta-Analysis of Controlled Clinical Trials
Michael J. Lipinski, MD*, ,2,
Giuseppe G.L. Biondi-Zoccai, MD ,2,*,
Antonio Abbate, MD,
Reena Khianey, MD,
Imad Sheiban, MD,
Jozef Bartunek, MD, PhD ,1,
Marc Vanderheyden, MD,1,
Hyo-Soo Kim, MD||,
Hyun-Jae Kang, MD||,
Bodo E. Strauer, MD# and
George W. Vetrovec, MD
* Department of Internal Medicine, University of Virginia, Charlottesville, Virginia
Virginia Commonwealth University, Pauley Heart Center, Richmond, Virginia
Interventional Cardiology, Division of Cardiology, University of Turin, Turin, Italy
Cardiovascular Center and Cardiovascular Research Center, Aalst, Belgium
|| Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea
# Department of Internal Medicine, Division of Cardiology, Pneumology, and Angiology, Heinrich Heine University, Duesseldorf, Germany.
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Figure 2 Impact of Intracoronary Cell Therapy on Left Ventricular Remodeling
Forest plots show the significantly beneficial impact of cell therapy after myocardial infarction on (A) left ventricular ejection fraction (EF), (B) end-systolic volume (ESV), (C) end-diastolic volume (EDV), and (D) infarct size/functional defect at myocardial scintigraphy or late enhancement at magnetic resonance imaging. CI = confidence interval; I2 = inconsistency; SE = standard error.
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Figure 3 Metaregression Between Injected Volume and Left Ventricular Remodeling
L’Abbé plot shows the overall trend toward a statistically significant association between average volume injected in the culprit coronary artery and average change in left ventricular ejection fraction (LVEF) across included studies (squares), with the size of each square proportional to sample size. This trend supports the presence of a dose-response relationship.
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