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J Am Coll Cardiol, 2007; 50:1657-1665, doi:10.1016/j.jacc.2007.07.029 (Published online 6 October 2007).
© 2007 by the American College of Cardiology Foundation
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Intravenous Iron Reduces NT-Pro-Brain Natriuretic Peptide in Anemic Patients With Chronic Heart Failure and Renal Insufficiency

Jorge Eduardo Toblli, MD, PhD*, Alejandra Lombraña, MD, Patricio Duarte, MD and Federico Di Gennaro, MD

Hospital Alemán, Buenos Aires, Argentina.


Figure 1
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Figure 1 Hemoglobin Concentration, TSAT, and Creatinine Clearance Throughout the Study

(A) Note that by the third month, there was a significant difference between the groups in hemoglobin level. (B) There was a significant difference in transferrin saturation (TSAT) by the third month. (C) There was a significant difference in creatinine clearance by the third month between the groups.

 

Figure 2
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Figure 2 NT-proBNP, CRP, and LVEF Evaluated in Both Groups Throughout the Study

(A) NT-pro-brain natriuretic peptide (NT-proBNP); (B) C-reactive protein (CRP); and (C) left ventricular ejection fraction (LVEF) evaluated by echocardiogram in both groups.

 

Figure 3
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Figure 3 Relationship Between NT-proBNP and Hemoglobin Level in Both Groups

A significant (p < 0.01) negative correlation between these 2 variables was seen in both groups at baseline (A), although only in group A at the end of the study (B). NT-proBNP = NT-pro brain natriuretic peptide.

 

Figure 4
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Figure 4 Relationship Between CRP and Hemoglobin Level in Both Groups

A significant (p < 0.01) negative correlation between these 2 variables in both groups was seen initially (A) and at the end of the study (B). CRP = C-reactive protein.

 




 
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