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Intensity of Statin Therapy in Relation to Myocardial Ischemia, Troponin T Release, and Clinical Cardiac Outcome in Patients Undergoing Major Vascular Surgery

Harm H.H. Feringa, MD^_*, Olaf Schouten, MD, Stefanos E. Karagiannis, MD^_*, Jasper Brugts, MD^_*, Abdou Elhendy, MD, Eric Boersma, PhD^_*, Radosav Vidakovic, MD^_*, Marc R.H.M. van Sambeek, MD, Peter G. Noordzij, MD, Jeroen J. Bax, MD^¶ and Don Poldermans, MD^,_*

^_* Department of Cardiology, Erasmus Medical Center, Rotterdam, the Netherlands
Department of Vascular Surgery, Erasmus Medical Center, Rotterdam, the Netherlands
Department of Anesthesiology, Erasmus Medical Center, Rotterdam, the Netherlands
Department of Cardiology, Marshfield Clinics, Marshfield, Wisconsin
^¶ Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.

View larger version (15K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Incidence of Myocardial Ischemia and Troponin T Release The lowest incidence of myocardial ischemia and troponin T release in the perioperative period was observed in patients with statin doses of more than 50% of the maximum recommended therapeutic dose.

View larger version (19K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Incidence of Myocardial Ischemia and Troponin T Release The incidence of myocardial ischemia and troponin T release in the perioperative period was lowest in patients with baseline low-density lipoprotein (LDL) cholesterol levels below 80 mg/dl.