Sirolimus-Eluting Stent Implantation Aggravates Endothelial Vasomotor Dysfunction in the Infarct-Related Coronary Artery in Patients With Acute Myocardial Infarction
Jyun-ei Obata, MD, PhD,
Yoshinobu Kitta, MD,
Hajime Takano, MD, PhD,
Yasushi Kodama, MD,
Takamitsu Nakamura, MD,
Akira Mende, MD,
Ken-ichi Kawabata, MD, PhD,
Yukio Saitoh, MD,
Daisuke Fujioka, MD,
Tsuyoshi Kobayashi, MD,
Toshiaki Yano, MD and
Kiyotaka Kugiyama, MD, PhD*
Department of Internal Medicine II, University of Yamanashi, Yamanashi Prefecture, Japan.
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Figure 1 Comparisons of Coronary Vasomotor Responses to ACh in AMI Patients and Control Subjects
Comparisons of vasomotor responses to acetylcholine (ACh) in acute myocardial infarction (AMI) patients treated with a sirolimus-eluting stent (SES) (n = 13) or bare-metal stent (BMS) (n = 16) and control subjects (n = 12). (A) Percent change in epicardial diameter of the left anterior descending coronary artery (LAD) from baseline in response to ACh. (B) Percent change in epicardial diameter of the left circumflex artery (LCx), a reference artery, from baseline in response to ACh. (C) Percent change in coronary blood flow (CBF) of the LAD from baseline in response to ACh.
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Figure 2 Comparisons of Coronary Vasomotor Responses to ISDNs or SNP in AMI Patients and Control Subjects
Comparisons of vasomotor responses to isosorbide dinitrates (ISDNs) or sodium nitroprusside (SNP) in AMI patients treated with an SES (n = 13) or BMS (n = 16) and control subjects (n = 12). (A) Percent change in epicardial diameter of the LAD and the LCx from baseline in response to ISDN. (B) Percent change in CBF of the LAD from baseline in response to SNP. Abbreviations as in Figure 1.
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Figure 3 VEGF Levels in the Plasma From the AIV and the AO in AMI Patients and in Control Subjects
Vascular endothelial growth factor (VEGF) levels (pg/ml) in the plasma from the anterior interventricular vein (AIV) and the aortic root (AO) at 2 weeks after AMI in AMI patients treated with an SES (n = 13) or BMS (n = 16) and in control subjects (n = 12). Abbreviations as in Figure 1.
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