Olmesartan, But Not Amlodipine, Improves Endothelium-Dependent Coronary Dilation in Hypertensive Patients
Masanao Naya, MD*,
Takahiro Tsukamoto, MD*, ,
Koichi Morita, MD ,
Chietsugu Katoh, MD ,
Tomoo Furumoto, MD*,
Satoshi Fujii, MD*,
Nagara Tamaki, MD and
Hiroyuki Tsutsui, MD*,*
* Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Department of Health Science, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Department of Cardiovascular Medicine, Date Red Cross Hospital, Date, Japan.
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Figure 1 Corrected MBF in Response to CPT Before and After Treatment
Corrected myocardial blood flow (MBF) in response to cold pressor test (CPT) before and after treatment with olmesartan (n = 13; left panel) and amlodipine (n = 13; right panel). The central bar on the vertical bars represents the mean ± SD.
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Figure 2  MBF in Response to CPT Before and After Treatment
The MBF from rest to CPT before and after treatment with olmesartan (n = 13) and amlodipine (n = 13). Abbreviations as in Figure 1.
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Figure 3 CVR in Response to CPT Before and After Treatment
The coronary vascular resistance (CVR) in response to cold pressor test (CPT) before and after treatment with olmesartan (n = 13; left panel) and amlodipine (n = 13; right panel). The central bar on the vertical bars represents the mean ± SD.
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Figure 4 CVR in Response to CPT Before and After Treatment
The CVR from rest to CPT before and after treatment with olmesartan (n = 13) and amlodipine (n = 13). Abbreviations as in Figure 3.
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Figure 5 Relationship Between the Changes of CVR During CPT and Serum SOD Activity After Treatment
Relationship between the changes in CVR during CPT and serum superoxide dismutase (SOD) activity after treatment with olmesartan (n = 13) (A) and amlodipine (n = 13) (B). Abbreviations as in Figure 3.
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