Diabetes Mellitus as a Predictor for Radial Artery Vasoreactivity in Patients Undergoing Coronary Artery Bypass Grafting
Bikram P. Choudhary, MRCS*,
Charalambos Antoniades, MD, PhD ,
Alison F. Brading, PhD ,
Antony Galione, PhD,
Keith Channon, MD, FRCP and
David P. Taggart, MD, PhD, FRCS*,*
* Department of Cardiothoracic Surgery, John Radcliffe Hospital, Oxford, United Kingdom
Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom
Department of Pharmacology, University of Oxford, Oxford, United Kingdom.
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Figure 1 Vasoconstrictive Responses of RA Grafts to Endogenous Vasoconstrictors
Dose-response curves of the vasoconstrictive responses of radial artery (RA) grafts to prostaglandin F2 (PGF2) (A), adrenaline (B), and angiotensin II (C) are presented. Values are expressed as mean ± SEM.
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Figure 2 The Effect of DM on the Responses of RA Grafts to Endogenous Vasoconstrictors
Radial artery (RA) from patients with diabetes mellitus (DM) had significantly greater vasomotor responses to adrenaline, angiotensin II, and prostaglandin F2 (PGF2) compared with nondiabetic patients. Values are expressed as mean ± SEM.
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Figure 3 The Effect of DM on the Vasoconstrictions of RA Grafts in Response to High K+ and the Vasorelaxations in Response to CCh
(A) There was no difference in radial artery (RA) contractions in response to high K+ between patients with diabetes mellitus (DM) and nondiabetic patients (p = NS). Values are expressed as median (25th to 75th percentile) and range. (B) The RA from patients with DM had lower relaxations in response to carbachol (CCh) (10–4 mol/l) compared with nondiabetic patients. Values are expressed as mean ± SEM.
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