Baseline Functional Performance Predicts the Rate of Mobility Loss in Persons With Peripheral Arterial Disease
Mary M. McDermott, MD*, ,*,
Jack M. Guralnik, MD, PhD ,
Lu Tian, ScD,
Luigi Ferrucci, MD, PhD ,
Kiang Liu, PhD,
Yihua Liao, MS and
Michael H. Criqui, MD, MPH¶
* Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland
Laboratory of Clinical Epidemiology, National Institute on Aging, Bethesda, Maryland
¶ Department of Family and Preventive Medicine, University of California at San Diego, San Diego, California.
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Figure 1 Hazard Ratios for Mobility Loss at 50-Month Follow-Up Among Men and Women With PAD, According to Baseline Functional Performance
Model 1: adjusts for age, gender, race, ankle-brachial index, body mass index, pack-years of cigarette smoking, leg symptoms, walking exercise frequency, and comorbidities. Model 2: Adjusts for variables in model 1 and blocks walked for exercise. Categories of performance: 6-min walk = Category 1 (lowest quartile):  1,001 ft; Category 2 (second quartile): 1,001 to 1,304 ft; Category 3 (third and fourth quartiles combined): >1,304 ft. 4-m walk (usual pace) = Category 1 (lowest quartile): 0.792 m/s; Category 2 (second quartile): 0.792 to 0.915 m/s; Category 3 (third and fourth quartiles combined): >0.915 m/s. 4-m walk (fast pace) = Category 1 (lowest quartile): 1.078 m/s; Category 2 (second quartile): 1.078 to 1.274 m/s; Category 3 (third and fourth quartiles combined): >1.274 m/s. Short Physical Performance Battery (0 to 12 scale, 12 = best) = Category 1: 1 to 8; Category 2: 9 to 10; Category 3: 11 to 12. *p < 0.01 relative to the highest 2 categories; **p < 0.05 relative to the highest 2 categories. PAD = peripheral arterial disease.
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Figure 2 Hazard Ratios for Mobility Loss at 50-Month Follow-Up Among Men and Women Without PAD, According to Baseline Functional Performance
Model 1: adjusts for age, gender, race, body mass index, pack-years of cigarette smoking, walking exercise frequency, and comorbidities. Model 2: adjusts for variables in model 1 and blocks walked for exercise. Categories of performance: 6-min walk = Category 1 (lowest quartile): 1,001 ft; Category 2 (second quartile): 1,001 to 1,304 ft; Category 3 (third and fourth quartiles combined): >1,304 ft. 4-m walk (usual pace) = Category 1 (lowest quartile): 0.792 m/s; Category 2 (second quartile): 0.797 to 0.915 m/s; Category 3 (third and fourth quartiles combined): >0.915 m/s. 4-m walk (fast pace) = Category 1 (lowest quartile): 1.078 m/s; Category 2 (second quartile): 1.078 to 1.274 m/s; Category 3 (third and fourth quartiles combined): >1.274 m/s. Short Physical Performance Battery (0 to 12 scale, 12 = best) = Category 1: 1 to 8; Category 2: 9 to 10; Category 3: 11 to 12. *p < 0.05 relative to the highest 2 quartiles; **p < 0.001 relative to the highest 2 quartiles. PAD = peripheral arterial disease.
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