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J Am Coll Cardiol, 2007; 49:925-932, doi:10.1016/j.jacc.2006.08.067 (Published online 15 February 2007).
© 2007 by the American College of Cardiology Foundation
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Intravascular Ultrasound for the Evaluation of Therapies Targeting Coronary Atherosclerosis

Dirk Böse, MD*, Clemens von Birgelen, MD, PhD{dagger} and Raimund Erbel, MD*,*

* Department of Cardiology, University of Duisburg-Essen, Essen, Germany
{dagger} Department of Cardiology, Medisch Spectrum Twente, Enschede, the Netherlands.


Figure 1
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  		Figure 1 IVUS Cross-Sectional Image of an Atherosclerotic Human Coronary Artery

Determination of plaque cross-sectional area using intravascular ultrasound (IVUS): external elastic membrane (EEM)–cross-sectional area (CSA) – Lumen-CSA = Plaque + Media-CSA.

 

Figure 2
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  		Figure 2 IVUS Cross-Sectional Image and Longitudinal Reconstruction of an Atherosclerotic Coronary Artery With a Plaque Rupture

(Left) Intravascular ultrasound (IVUS) cross-sectional image; (right) longitudinal reconstruction. The line indicates the position of the cross-sectional image and thus the site of plaque rupture in the longitudinal reconstruction.

 

Figure 3
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  		Figure 3 Plaque Progression/Regression Versus CV Events

Higher rate of cardiovascular (CV) events in patients with plaque progression during follow-up. Modified from von Birgelen et al. (27). PCI = percutaneous coronary intervention; P&M = plaque and media.

 

Figure 4
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  		Figure 4 Cholesterol Levels Versus Plaque Progression Regression

(Top) Positive relation between plaque progression, defined as change in plaque plus media cross-sectional area/year ({Delta}P&M CSA/year), versus LDL-C levels. (Bottom) Negative relation between plaque progression ({Delta}P&M CSA/year) versus HDL-C levels. Modified from von Birgelen et al. (33). CSA = cross-sectional area; HDL-C = high-density lipoprotein cholesterol; LDL-C = low-density lipoprotein cholesterol; P&M = plaque and media.

 

Figure 5
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  		Figure 5 LDL-C Versus Coronary Plaque Progression/Regression

(Left) First demonstration of the positive correlation between coronary plaque progression by intravascular ultrasound and LDL-C levels in an observational study. Modified from von Birgelen et al. (33). (Right) Confirmation of the relation between LDL-C and coronary plaque progression by data derived from various large randomized trials. Modified from Nissen SE et al. (36). LDL-C = low-density lipoprotein cholesterol; P&M = plaque and media.

 




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Copyright © 2007 by the American College of Cardiology Foundation.