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J Am Coll Cardiol, 2007; 49:698-705, doi:10.1016/j.jacc.2006.06.082 (Published online 25 January 2007).
© 2007 by the American College of Cardiology Foundation
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Roles of Rho-Associated Kinase and Oxidative Stress in the Pathogenesis of Aortic Stiffness

Kensuke Noma, MD, PhD*, Chikara Goto, RPT, MS, PhD*, Kenji Nishioka, MD*, Daisuke Jitsuiki, MD*, Takashi Umemura, MD*, Keiko Ueda, MD, PhD{dagger}, Masashi Kimura, MD, PhD{dagger}, Keigo Nakagawa, MD, PhD{dagger}, Tetsuya Oshima, MD, PhD{ddagger}, Kazuaki Chayama, MD, PhD{dagger}, Masao Yoshizumi, MD, PhD*, James K. Liao, MD§ and Yukihito Higashi, MD, PhD, FAHA*,*

* Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
{dagger} Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
{ddagger} Department of Clinical Laboratory Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
§ Vascular Medicine Research Unit, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts.


Figure 1
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  		Figure 1 FBF Response to SNP

Results are presented as mean ± SEM. The probability value refers to a comparison of time course curves by analysis of variance for repeated measurements. *p < 0.01 versus basal forearm blood flow (FBF) assessed by Bonferroni correction. SNP = sodium nitroprusside.

 

Figure 2
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  		Figure 2 FBF Response to ACh

Results are presented as mean ± SEM. The probability value refers to a comparison of time course curves by analysis of variance for repeated measurements. *p < 0.05; {dagger}p < 0.01 versus basal forearm blood flow (FBF) assessed by Bonferroni correction. ACh = acetylcholine.

 

Figure 3
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  		Figure 3 FBF Response to Fasudil Alone and After Co-Infusion of L-NMMA

Results are presented as mean ± SEM. The probability value refers to a comparison of time course curves by analysis of variance for repeated measurements in each group. *p < 0.01 versus basal forearm blood flow (FBF) of fasudil alone; {dagger}p < 0.01 versus basal FBF after co-infusion of N G-monomethyl-L-arginine (L-NMMA) assessed by Bonferroni correction.

 




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Copyright © 2007 by the American College of Cardiology Foundation.