JACC
HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK
QUICK SEARCH:   [advanced]


     

J Am Coll Cardiol, 2007; 49:675-683, doi:10.1016/j.jacc.2006.07.073 (Published online 25 January 2007).
© 2007 by the American College of Cardiology Foundation
This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow View UNLOAD Trial Investigators
Right arrow View Correction to Author Disclosure
Right arrow Correction (v49,p1136)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (43)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Costanzo, M. R.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Costanzo, M. R.
Related Collections
Right arrowRelated Article

Ultrafiltration Versus Intravenous Diuretics for Patients Hospitalized for Acute Decompensated Heart Failure

Maria Rosa Costanzo, MD, FACC*,1,*, Maya E. Guglin, MD, FACC{dagger}, Mitchell T. Saltzberg, MD, FACC*,2, Mariell L. Jessup, MD, FACC{ddagger}, Bradley A. Bart, MD, FACC§, John R. Teerlink, MD, FACC||, Brian E. Jaski, MD, FACC, James C. Fang, MD, FACC#, Erika D. Feller, MD, FACC**, Garrie J. Haas, MD, FACC{dagger}{dagger}, Allen S. Anderson, MD, FACC{ddagger}{ddagger}, Michael P. Schollmeyer, DVM§§,4, Paul A. Sobotka, MD, FACC§§,3 for the UNLOAD Trial Investigators

* Midwest Heart Foundation, Lombard, Illinois
{dagger} John D. Dingell VA Medical Center, Division of Cardiology, Department of Medicine, Wayne State University, Detroit, Michigan
{ddagger} Division of Cardiology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
§ Division of Cardiology, Department of Medicine, Hennepin County Medical Center, Minneapolis, Minnesota
|| San Francisco Veterans Affairs Medical Center/University of California, San Francisco, California
San Diego Cardiac Center, Sharp Memorial Hospital, San Diego, California
# Division of Cardiology, Department of Medicine, Brigham and Women’s Hospital, Harvard University, Boston, Massachusetts
** Division of Cardiology, Department of Medicine, University of Maryland, Baltimore, Maryland
{dagger}{dagger} Division of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio
{ddagger}{ddagger} Division of Cardiology, Department of Medicine, University of Chicago, Chicago, Illinois
§§ CHF Solutions, Brooklyn Park, Minnesota


Figure 1
View larger version (24K):
[in this window]
[in a new window]
[Download PPT slide]
  		Figure 1 Primary Efficacy and Safety End Points

(A) Mean weight loss in kilograms; (B) mean dyspnea score (from 1 = markedly worse to 7 = markedly better) at 48 h after randomization in the ultrafiltration (blue circles) and standard-care (red circles) groups; p values are for the comparison between ultrafiltration and standard care. Error bars indicate 95% confidence intervals (CIs). (C) Mean changes from baseline serum creatinine levels at 8, 24, 48, and 72 h after randomization; at discharge; and 10, 30, and 90 days in the ultrafiltration (red bars) and standard-care (blue bars) groups. Error bars indicate 95% CIs. Differences between groups at each time point were evaluated with the Wilcoxon’s rank-sum test; p > 0.05 at all time points for the comparison of mean change in serum creatinine levels between groups.

 

Figure 2
View larger version (17K):
[in this window]
[in a new window]
[Download PPT slide]
  		Figure 2 Freedom From Heart Failure Rehospitalization

Kaplan-Meier estimate of freedom from rehospitalization for heart failure within 90 days after discharge in the ultrafiltration (red line) and standard care (blue line) groups.

 

Figure 3
View larger version (31K):
[in this window]
[in a new window]
[Download PPT slide]
  		Figure 3 Hazard Ratios for Heart Failure Rehospitalization According to Selected Baseline Characteristics

Cox proportional hazards analysis estimate of hazard ratios and their 95% confidence intervals (CIs) for rehospitalization owing to heart failure according to selected baseline characteristics of the study patients.

 




HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK
Copyright © 2007 by the American College of Cardiology Foundation.