Long QT Syndrome in Adults
Andrew J. Sauer, BS*,
Arthur J. Moss, MD*,*,
Scott McNitt, MS*,
Derick R. Peterson, PhD ,
Wojciech Zareba, MD, PhD*,
Jennifer L. Robinson, MS*,
Ming Qi, PhD ,
Ilan Goldenberg, MD*,
Jenny B. Hobbs, BA*,
Michael J. Ackerman, MD, PhD ,
Jesaia Benhorin, MD||,
W. Jackson Hall, PhD,
Elizabeth S. Kaufman, MD¶,
Emanuela H. Locati, MD, PhD#,
Carlo Napolitano, MD**,
Silvia G. Priori, MD, PhD**,
Peter J. Schwartz, MD,
Jeffrey A. Towbin, MD,
G. Michael Vincent, MD and
Li Zhang, MD
* Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, New York
Department of Biostatistics, University of Rochester Medical Center, Rochester, New York
Department of Pathology, University of Rochester Medical Center, Rochester, New York
Departments of Medicine, Pediatrics, and Molecular Pharmacology, Mayo Clinic College of Medicine, Rochester, Minnesota
|| Department of Cardiology, Bikur Cholim Hospital, Jerusalem, Israel
¶ The Heart and Vascular Research Center, MetroHealth Campus, Case Western Reserve University, Cleveland, Ohio
# Section of Cardiology, Department of Clinical and Experimental Medicine, Universita Degli Studi Di Perugia, Perugia, Italy
** Molecular Cardiology, Fondazione S. Maugeri-University of Pavia, Pavia, Italy
Department of Cardiology, Policlinico S. Matteo IRCCS and University of Pavia, Pavia, Italy
Department of Pediatric Cardiology, Baylor College of Medicine, Houston, Texas
Department of Medicine, University of Utah Medical School, Salt Lake City, Utah.
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Figure 1 Probability of Any Cardiac Event
Kaplan-Meier estimate of the cumulative probability of any cardiac event (syncope/aborted cardiac arrest [ACA]/long QT syndrome [LQTS]-related sudden death) after age 18 years among mutation-carrying subjects on the basis of: (A) corrected QT interval; (B) number of cardiac events before age 18 years; (C) gender; and (D) genotype. The p value was computed with the log-rank test, and they are unadjusted for covariates. The numbers of subjects remaining at risk are given at 5-year intervals beginning at age 25 years, with the numbers in parentheses indicating the cumulative probability of a cardiac event at the specified age.
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Figure 2 Probability of ACA or LQTS-Related Death
Kaplan-Meier estimate of the cumulative probability of aborted cardiac arrest (ACA) or long QT syndrome (LQTS)-related sudden death (syncope excluded) after age 18 years among mutation-carrying subjects on the basis of: (A) corrected QT interval; (B) number of cardiac events before age 18 years; (C) gender; and (D) genotype. The p value was computed with the log-rank test and is unadjusted for covariates. The numbers of subjects remaining at risk are given at 5-year intervals beginning at age 25 years, with the numbers in parentheses indicating the cumulative probability of a cardiac event at the specified age.
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