Advertisement

Submit Manuscripts
Author Information
Subscribe/Renew
Order Reprints
Email Alerts
Feedback
RSS Feed
CME

About the Journal
Editorial Board & Staff

About JACC CME
Hardware/Software Requirements
Contact Us
Policy on Privacy and Confidentiality
Copyright Information

JACC Imaging Homepage JACC Interventions Homepage
Still not a subscriber to JACC Imaging or JACC Interventions?
Click here
to sign up now!

ACC.org
Cardiosmart
Cardiosource
CVN
Imaging Library
JACC Imaging
JACC Interventions

Click here for more guidelines.
2009 Focused Updates: ACC/AHA Guidelines for STEMI and ACC/AHA/SCAI Guidelines for PCI
2009 ACCF/AHA Focused Update on Perioperative Beta Blockade Incorporated Into the ACC/AHA 2007 Guidelines on Perioperative Cardiovascular Evaluation and Care for Noncardiac Surgery
ACC 2009 Advocacy Position Statement: Principles for Comparative Effectiveness Research
CME Topic Collections Past Issues Search Current Issue Home
     

J Am Coll Cardiol, 2007; 49:304-310, doi:10.1016/j.jacc.2006.08.053 (Published online 3 January 2007).
© 2007 by the American College of Cardiology Foundation
This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (18)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Worthley, M. I.
Right arrow Articles by Horowitz, J. D.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Worthley, M. I.
Right arrow Articles by Horowitz, J. D.

The Deleterious Effects of Hyperglycemia on Platelet Function in Diabetic Patients With Acute Coronary Syndromes

Mediation by Superoxide Production, Resolution With Intensive Insulin Administration

Matthew I. Worthley, MBBS, PhD, Andrew S. Holmes, PhD, Scott R. Willoughby, PhD, Angela M. Kucia, BN, PhD, Tamila Heresztyn, BSc, Simon Stewart, PhD, FESC, Yuliy Y. Chirkov, BSc, PhD, Christopher J. Zeitz, MBBS, PhD and John D. Horowitz, MBBS, PhD*

Cardiology Unit, Basil Hetzel Research Institute, The Queen Elizabeth Hospital, University of Adelaide, South Australia, Australia.


Figure 1
View larger version (15K):
[in this window]
[in a new window]
[Download PPT slide]
  		Figure 1 Relationship Between Platelet SNP Response and Admission BSL (r = –0.31, p = 0.007)

BSL = blood sugar level; SNP = sodium nitroprusside.

 

Figure 2
View larger version (13K):
[in this window]
[in a new window]
[Download PPT slide]
  		Figure 2 Relationship Between Log Lucigenin-Derived LDCL and Admission BSL (r = 0.43, p < 0.001)

BSL = blood sugar level; LDCL = lucigenin-derived chemiluminescence.

 

Figure 3
View larger version (11K):
[in this window]
[in a new window]
[Download PPT slide]
  		Figure 3 Differential Effects of IV and SC Insulin Therapy on Changes Over 12 h

(A) Platelet sodium nitroprusside (SNP) response (p = 0.049), (B) superoxide generation (p < 0.001), and (C) asymmetric dimethylarginine (ADMA) levels (p = 0.049). IV = intravenous; LDLC = lucigenin-derived chemiluminescence; SC = subcutaneous.

 
 
  CME Topic Collections Past Issues Search Current Issue Home

Advertisement