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J Am Coll Cardiol, 2007; 49:304-310, doi:10.1016/j.jacc.2006.08.053 (Published online 3 January 2007).
© 2007 by the American College of Cardiology Foundation
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The Deleterious Effects of Hyperglycemia on Platelet Function in Diabetic Patients With Acute Coronary Syndromes

Mediation by Superoxide Production, Resolution With Intensive Insulin Administration

Matthew I. Worthley, MBBS, PhD, Andrew S. Holmes, PhD, Scott R. Willoughby, PhD, Angela M. Kucia, BN, PhD, Tamila Heresztyn, BSc, Simon Stewart, PhD, FESC, Yuliy Y. Chirkov, BSc, PhD, Christopher J. Zeitz, MBBS, PhD and John D. Horowitz, MBBS, PhD*

Cardiology Unit, Basil Hetzel Research Institute, The Queen Elizabeth Hospital, University of Adelaide, South Australia, Australia.


Figure 1
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  		Figure 1 Relationship Between Platelet SNP Response and Admission BSL (r = –0.31, p = 0.007)

BSL = blood sugar level; SNP = sodium nitroprusside.

 

Figure 2
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  		Figure 2 Relationship Between Log Lucigenin-Derived LDCL and Admission BSL (r = 0.43, p < 0.001)

BSL = blood sugar level; LDCL = lucigenin-derived chemiluminescence.

 

Figure 3
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  		Figure 3 Differential Effects of IV and SC Insulin Therapy on Changes Over 12 h

(A) Platelet sodium nitroprusside (SNP) response (p = 0.049), (B) superoxide generation (p < 0.001), and (C) asymmetric dimethylarginine (ADMA) levels (p = 0.049). IV = intravenous; LDLC = lucigenin-derived chemiluminescence; SC = subcutaneous.

 




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Copyright © 2007 by the American College of Cardiology Foundation.