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J Am Coll Cardiol, 2007; 49:2341-2349, doi:10.1016/j.jacc.2007.01.095 (Published online 1 June 2007).
© 2007 by the American College of Cardiology Foundation
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Selective Functional Exhaustion of Hematopoietic Progenitor Cells in the Bone Marrow of Patients With Postinfarction Heart Failure

Christine K. Kissel, MD1, Ralf Lehmann, MD, Birgit Assmus, MD, Alexandra Aicher, MD, Jörg Honold, MD, Ulrich Fischer-Rasokat, MD, Christopher Heeschen, MD, Ioakim Spyridopoulos, MD, Stefanie Dimmeler, PhD and Andreas M. Zeiher, MD*

Department of Cardiology, Johann Wolfgang Goethe–University Frankfurt, Frankfurt, Germany.


Figure 1
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  		Figure 1 Number of EPCs in CHF Patients Compared With Healthy Volunteers

Data are presented as mean ± SD. CHF = chronic heart failure; DCM = dilated cardiomyopathy; EPC = endothelial progenitor cell; ICM = ischemic cardiomyopathy; n.s. = not significant.

 

Figure 2
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  		Figure 2 Functional Impairment of EPCs as Assessed by VEGF-Induced Migratory Capacity

Data are presented as mean ± SD. VEGF = vascular endothelial growth factor; other abbreviations as in Figure 1.

 

Figure 3
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  		Figure 3 Number of Hematopoietic Precursor Cells as Assessed by FACS Analysis of Marker Proteins

The percentages of total cells are depicted as mean ± SD. FACS = fluorescent-activated cell sorting; other abbreviations as in Figure 1.

 

Figure 4
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  		Figure 4 Colony-Forming Activity of BM-MNCs

Data are shown as mean ± SD. BM-MNC = bone marrow-derived mononuclear cell; other abbreviations as in Figure 1.

 




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Copyright © 2007 by the American College of Cardiology Foundation.