J Am Coll Cardiol, 2007; 49:2238-2246, doi:10.1016/j.jacc.2007.01.093 (Published online 24 May 2007). © 2007 by the American College of Cardiology Foundation

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Percutaneous Coronary Intervention in Patients Receiving Enoxaparin or Unfractionated Heparin After Fibrinolytic Therapy for ST-Segment Elevation Myocardial Infarction in the ExTRACT-TIMI 25 Trial

C. Michael Gibson, MS, MD, FACC^_*, Sabina A. Murphy, MPH^_*, Gilles Montalescot, MD, David A. Morrow, MD, MPH, FACC, Diego Ardissino, MD, Marc Cohen, MD^||, Dietrich C. Gulba, MD^¶, Oscar H. Kracoff, MD^#, Basil S. Lewis, MD, FACC^_**, Nathan Roguin, MD, Elliott M. Antman, MD, FACC^,_*, Eugene Braunwald, MD, MACC for the ExTRACT-TIMI 25 Investigators

^_* Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, Massachusetts
Institut du Coeur, Centre Hospitalier Universitaire Pitié-Salpêtrière, Paris, France
Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts
Universita di Pavia, Parma, Italy
^|| Newark Beth Israel Medical Center, Newark, New Jersey
^¶ Krankenhaus Duren Gem Mediziniche Klinik I, Duren, Germany
^# Kaplan Medical Center, Rehovot, Israel
^_** Lady Davis Carmel Medical Center, Haifa, Israel
Nahariya Hospital, Nahariya, Israel.

View larger version (11K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Study Profile Number of patients in the enoxaparin (ENOX) and unfractionated heparin (UFH) groups treated with coronary artery bypass graft (CABG), medical therapy, and percutaneous coronary intervention (PCI).

View larger version (11K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Kaplan-Meier Failure Estimates for PCI by Randomization Group PCI was performed less frequently in the ENOX group than in the UFH group (p = 0.02 by log rank). Abbreviations as in Figure 1.

View larger version (10K): [in this window] [in a new window] [Download PPT slide]   Figure 3 KM Failure for 30-Day Death or Recurrent MI by Randomization Group in the PCI Cohort Death or recurrent MI occurred less frequently in the ENOX group compared with the UFH group in the PCI cohort (p = 0.001 by log rank). KM = Kaplan-Meier; MI = myocardial infarction; other abbreviations as in Figure 1.

View larger version (27K): [in this window] [in a new window] [Download PPT slide]   Figure 4 Risk of 30-Day Death or Nonfatal Recurrent MI by Randomization Group According to Subgroups Among Patients Who Underwent PCI GP = glycoprotein; Hx = history; SK = streptokinase; Sx = symptom; other abbreviations as in Figures 1 and 3.