Plasma Concentrations of Myeloperoxidase Predict Mortality After Myocardial Infarction
Tessa J. Mocatta, MSc*,
Anna P. Pilbrow, PhD ,
Vicky A. Cameron, PhD,
Revathy Senthilmohan, PhD,
Chris M. Frampton, PhD,
A. Mark Richards, MD, PhD and
Christine C. Winterbourn, PhD*,*
* Department of Pathology, Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand
Department of Medicine, Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand.
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Figure 1 Plasma Concentrations of Myeloperoxidase and Protein Carbonyls in Patients After MI
(A) Myeloperoxidase and (B) protein carbonyls, with patient data in red and control data in blue. Boxes show medians and interquartile ranges with whiskers and symbols representing the 10th/90th and 5th/95th percentiles, respectively. Both markers were significantly higher for patients than control subjects (p < 0.001). MI = myocardial infarction.
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Figure 2 Kaplan-Meier Cumulative Survival Curves for MI Patients Show a Difference for MPO But Not PCs
(A) Comparison of patients with (red) above-median and (blue) below-median myeloperoxidase (MPO) concentrations (median 55 ng/ml; p = 0.001); and (B) patients with above- and below-median protein carbonyls (median 48 pmol/mg; p = 0.31), over a 5-year follow-up. MI = myocardial infarction; PC = protein carbonyl.
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Figure 3 MPO Provides Further Discrimination in Survival When Combined With LVEF or NT-proBNP
Kaplan-Meier cumulative survival curves for myocardial infarction patients with above- and below-median myeloperoxidase (MPO) over a 5-year follow-up in combination with (A) above- and below-median left ventricular ejection fraction (LVEF) (p < 0.0001) and (B) above- and below-median plasma amino-terminal pro-brain natriuretic peptide (NT-proBNP) levels (p < 0.0001). Differences in survival between patient groups are indicated, except for between groups A and B where there was no significant difference. Medians: MPO = 55 ng/ml; protein carbonyls = 48 pmol/mg; LVEF = 49%; NT-proBNP = 110 pmol/l.
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Figure 4 Relationships Between Protein Carbonyls and 3-Chlorotyrosine
The oxidative markers were generated in human serum albumin (solid triangles) and normal plasma (open triangles) by treatment with hypochlorous acid (HOCl) and compared with those for myocardial infarction plasmas (circles). CI-Tyr = chlorotyrosine; PMI = post-myocardial infarction; Tyr = tyrosine.
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