Early Increase of Oxidative Stress and Soluble CD40L in Children With Hypercholesterolemia
Francesco Martino, MD*,*,
Pasquale Pignatelli, MD ,
Eliana Martino, MD*,
Francesco Morrone, MD*,
Roberto Carnevale, PhD,
Serena Di Santo, PhD,
Barbara Buchetti, PhD,
Lorenzo Loffredo, MD and
Francesco Violi, MD
* Center of Clinic Lipid Research, Department of Pediatrics, University of Rome "La Sapienza," Rome, Italy
Department of Experimental Medicine and Pathology, University of Rome "La Sapienza," Rome, Italy.
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Figure 2 Regression Analysis Between LDL Cholesterol and 8-OHdG
Linear regression analysis between low-density lipoprotein (LDL) cholesterol and 8-OHdG serum levels in hypercholesterolemic children (A) and adults (B). Other abbreviations as in Figure 1.
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Figure 4 Regression Analysis Between LDL Cholesterol and sCD40L
Linear regression analysis between LDL cholesterol and sCD40L plasma levels in hypercholesterolemic children (A) and adults (B). Abbreviations as in Figures 1 to 3.
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Figure 5 Regression Analysis Between sCD40L and 8-OHdG
Linear regression analysis between sCD40L and 8-OHdG in hypercholesterolemic children (A) and adults (B). Abbreviations as in Figures 1 and 3.
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Figure 6 p38 MAPK Phosphorylation Analysis
(A) p38 mitogen-activated protein kinase (p38MAPK) phosphorylation analysis in normocholesterolemic (HS) (n = 8) and hypercholesterolemic (HC) children (n = 8) (the rate of phosphorylation was expressed as arbitrary units [AU]) (*p < 0.001). (B) A representative Western blot analysis of p38MAPK phosphorylation in normocholesterolemic (HS) (n = 4) and hypercholesterolemic (HC) (n = 4) children.
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