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J Am Coll Cardiol, 2007; 49:1934-1942, doi:10.1016/j.jacc.2007.01.080 (Published online 30 April 2007).
© 2007 by the American College of Cardiology Foundation
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Genetic Variants in P-Selectin and C-Reactive Protein Influence Susceptibility to Cognitive Decline After Cardiac Surgery

Joseph P. Mathew, MD*,*, Mihai V. Podgoreanu, MD*, Hilary P. Grocott, MD*, William D. White, MPH*, Richard W. Morris, PhD*, Mark Stafford-Smith, MD*, G. Burkhard Mackensen, MD*, Christine S. Rinder, MD||, James A. Blumenthal, PhD{dagger}, Debra A. Schwinn, MD*,{ddagger},§, Mark F. Newman, MD* for the PEGASUS Investigative Team

* Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina
{dagger} Department of Psychiatry, Duke University Medical Center, Durham, North Carolina
{ddagger} Department of Pharmacology/Cancer Biology, Duke University Medical Center, Durham, North Carolina
§ Duke Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina
|| Departments of Anesthesiology and Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut.


Figure 1
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  		Figure 1 Incidence of Postoperative Cognitive Deficit by CRP 1059G/C and SELP 1087G/A Genotypes

The incidence of cognitive deficit was 16.7% in carriers of minor alleles at both of these loci compared with 42.9% in patients homozygous for the major allele. CRP = C-reactive protein; SELP = P-selectin. n = 386.

 

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  		Figure 2 Median CRP Levels by CRP 1059G/C Genotypes

C-reactive protein (CRP) levels at the 24-h sampling time in patients homozygous (C/C) or heterozygous (C/G) for the minor allele were lower compared with patients homozygous (G/G) for the major allele. n = 225. *p < 0.05.

 

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  		Figure 3 Median Platelet Activation (Relative to Baseline) by SELP 1087G/A Genotypes

Platelet activation was significantly lower upon release of the cross-clamp in patients with the homozygous minor (A/A) or heterozygous (G/A) genotype compared with patients homozygous (G/G) for the major allele. CPB = cardiopulmonary bypass; SELP = P-selectin. n = 93. *p < 0.05.

 




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