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J Am Coll Cardiol, 2007; 49:1733-1739, doi:10.1016/j.jacc.2006.10.081 (Published online 30 March 2007).
© 2007 by the American College of Cardiology Foundation
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Plasma Brain Natriuretic Peptide-Guided Therapy to Improve Outcome in Heart Failure

The STARS-BNP Multicenter Study

Patrick Jourdain, MD*,{dagger},{ddagger},*, Guillaume Jondeau, MD, PhD§, François Funck, MD{ddagger}, Pascal Gueffet, MD||, Alain Le Helloco, MD, Erwan Donal, MD, Jean F. Aupetit, MD#, Marie C. Aumont, MD§, Michel Galinier, MD, PhD**, Jean C. Eicher, MD{dagger}{dagger}, Alain Cohen-Solal, MD, PhD{ddagger}{ddagger} and Yves Juillière, MD, PhD§§

* René Descartes University, Paris, France
{dagger} Georges Pompidou Hospital, Paris, France
§ Department of Cardiology, Bichat University Hospital, Paris, France
{ddagger}{ddagger} Department of Cardiology, Centre Hospitalier Universitaire de Lariboisière, Paris, France
{ddagger} Hospitalier de Rene Dubos, Pontoise, France
|| Centre Hospitalier Universitaire de Nantes, Nantes, France
Centre Hospitalier Universitaire de Rennes, Rennes, France
# Hopital Saint Luc Lyon, Lyon, France
** Department of Cardiology, Centre Hospitalier Universitaire de Toulouse, Toulouse, France
{dagger}{dagger} Centre Hospitalier Universitaire de Dijon, Dijon, France
§§ Department of Cardiology, Centre Hospitalier Universitaire de Vandoeuvre Les Nancy, Vandoeuvre Les Nancy, France.


Figure 1
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  		Figure 1 Number of Changes in Medical Therapy During the First 3 Months

Changes were related to high brain natriuretic peptide (BNP) value according to protocol or clinical reasons.

 

Figure 2
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  		Figure 2 Changes in Medical Therapy During the Titration Phase in BNP Group and Clinical Group

Therapeutic modifications during titration phase. ACEI = angiotensin-converting enzyme inhibitor; BNP = brain natriuretic peptide.

 

Figure 3
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  		Figure 3 Evolution of Systolic Blood Pressure, Heart Rate, Weight, and Creatininemia During the First 3 Months

Hemodynamic and biological variations during titration phase. BNP = brain natriuretic peptide; M = month.

 

Figure 4
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  		Figure 4 Event-Free (Hospital Stay for Heart Failure or Death Related to Heart Failure) Survival in the 2 Groups

Event-free survival. BNP = brain natriuretic peptide.

 

Figure 5
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  		Figure 5 Plasma BNP Level in BNP Group During Titration Phase and % of Patients Reaching Target BNP Value

BNP = brain natriuretic peptide; M = month.

 




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Copyright © 2007 by the American College of Cardiology Foundation.