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J Am Coll Cardiol, 2007; 49:1619-1624, doi:10.1016/j.jacc.2006.12.043 (Published online 30 March 2007).
© 2007 by the American College of Cardiology Foundation
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Increased Rho Kinase Activity in a Taiwanese Population With Metabolic Syndrome

Ping-Yen Liu, MD, PhD*,{dagger},{ddagger},1, Jyh-Hong Chen, MD, PhD, FACC*,{dagger}, Li-Jen Lin, MD*,{dagger} and James K. Liao, MD, FACC{ddagger},*

* Division of Cardiology, Internal Medicine, National Cheng Kung University, Tainan, Taiwan
{dagger} Cardiovascular Research Center, National Cheng Kung University, Tainan, Taiwan
{ddagger} Vascular Medicine Research Unit, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts.


Figure 1
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  		Figure 1 ROCK Activity Is Greater Among Asian Subjects With MetS

(A) Baseline protein expression of Rho kinase (ROCK)1 by immunoblotting method; (B) baseline protein expression of ROCK2 by immunoblotting method; (C) phosphorylation levels of MBS (pMBS) and total MBS (tMBS) were determined by immunoblotting methods; (D) ROCK activity, expressed as pMBS/MBS, between metabolic syndrome (MetS) patients and controls. Three repeated experiments were performed in duplicate.

 

Figure 2
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  		Figure 2 ROC Analysis to Determine the Cutoff Value to Differentiate MetS

The best cutoff value for Rho kinase activity to differentiate the presence of metabolic syndrome (MetS) was 0.39; both sensitivity and specificity rates were 70%. The area under the curve = 0.76 ± 0.07, p = 0.001. ROC = receiver-operating characteristic.

 




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