Increased Rho Kinase Activity in a Taiwanese Population With Metabolic Syndrome
Ping-Yen Liu, MD, PhD*, , ,1,
Jyh-Hong Chen, MD, PhD, FACC*,,
Li-Jen Lin, MD*, and
James K. Liao, MD, FACC,*
* Division of Cardiology, Internal Medicine, National Cheng Kung University, Tainan, Taiwan
Cardiovascular Research Center, National Cheng Kung University, Tainan, Taiwan
Vascular Medicine Research Unit, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts.
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Figure 1 ROCK Activity Is Greater Among Asian Subjects With MetS
(A) Baseline protein expression of Rho kinase (ROCK)1 by immunoblotting method; (B) baseline protein expression of ROCK2 by immunoblotting method; (C) phosphorylation levels of MBS (pMBS) and total MBS (tMBS) were determined by immunoblotting methods; (D) ROCK activity, expressed as pMBS/MBS, between metabolic syndrome (MetS) patients and controls. Three repeated experiments were performed in duplicate.
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Figure 2 ROC Analysis to Determine the Cutoff Value to Differentiate MetS
The best cutoff value for Rho kinase activity to differentiate the presence of metabolic syndrome (MetS) was 0.39; both sensitivity and specificity rates were 70%. The area under the curve = 0.76 ± 0.07, p = 0.001. ROC = receiver-operating characteristic.
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