Improved Outcomes After Aortic Valve Surgery for Chronic Aortic Regurgitation With Severe Left Ventricular Dysfunction
Sunil K. Bhudia, MD*,
Patrick M. McCarthy, MD*,*,
Ganesh S. Kumpati, MD*,
Joe Helou, MD*,
Katherine J. Hoercher, RN*,
Jeevanantham Rajeswaran, MSc and
Eugene H. Blackstone, MD*,
* Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio
Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio.
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Figure 1 Mortality After Aortic Valve Surgery in Propensity-Matched Patients With and Without Severe LVD
(A) Survival. Each square (severe left ventricular dysfunction [LVD] group) and circle (nonsevere LVD group) represents an event; vertical bars represent confidence intervals equivalent to ±1 standard error (68% confidence limit). Numbers in parentheses represent patients at risk for death. Solid lines are parametric estimates enclosed within 68% confidence limits. (B) Hazard ratio comparing hazard for death of patients with severe versus nonsevere LVD enclosed within 68% confidence limits.
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Figure 2 Hospital Mortality in Propensity-Matched Patients Across the Clinical Experience
Solid lines are parametric trend lines enclosed within dashed 68% confidence limits. Aggregated raw mortality is represented by symbols (squares for severe LVD group and circles for the nonsevere group). Abbreviations as in Figure 1.
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Figure 3 Ten-Year Predicted Survival in Propensity-Matched Patients According to Date of Operation
Data derived from a multivariable model containing group (severe vs. nonsevere LVD), date of operation, and interaction of group with date of operation. Solid lines represent parametric estimates enclosed within 68% confidence limits. Abbreviations as in Figure 1.
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Figure 4 Survival in Propensity-Matched Patients Undergoing Surgery in 1985 and Beyond
Depiction is as in Figure 1A. Solid lines represent predicted survival obtained for each matched patient by solving the overall, multivariable risk-adjusted equation in Table 3. They are enclosed within 68% confidence limits. Abbreviations as in Figure 1.
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